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Trypanosomatid Flagellar Pocket from Structure to Function
Trends in Parasitology ( IF 9.6 ) Pub Date : 2020-12-08 , DOI: 10.1016/j.pt.2020.11.005
Clare Halliday 1 , Artur de Castro-Neto 1 , Carolina L Alcantara 2 , Narcisa L Cunha-E-Silva 2 , Sue Vaughan 1 , Jack D Sunter 1
Affiliation  

The trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. are flagellate eukaryotic parasites that cause serious diseases in humans and animals. These parasites have cell shapes defined by a subpellicular microtubule array and all share a number of important cellular features. One of these is the flagellar pocket, an invagination of the cell membrane around the proximal end of the flagellum, which is an important organelle for endo/exocytosis. The flagellar pocket plays a crucial role in parasite pathogenicity and persistence in the host and has a great influence on cell morphogenesis and cell division. Here, we compare the morphology and function of the flagellar pockets between different trypanosomatids, with their life cycles and ecological niches likely influencing these differences.



中文翻译:

从结构到功能的锥虫鞭毛囊

该锥虫布氏锥虫克氏锥虫,利什曼原虫属 鞭毛虫是真核寄生虫,可引起人类和动物的严重疾病。这些寄生虫具有由亚膜微管阵列定义的细胞形状,并且都具有许多重要的细胞特征。其中之一是鞭毛袋,鞭毛近端周围的细胞膜内陷,是胞内/胞吐作用的重要细胞器。鞭毛袋在寄主体内寄生虫的致病性和持久性方面起着至关重要的作用,并且对细胞形态发生和细胞分裂有很大影响。在这里,我们比较了不同锥虫的鞭毛袋的形态和功能,它们的生命周期和生态位可能会影响这些差异。

更新日期:2020-12-08
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