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Investigation of non-volatile substances in the Haihong fruit wine and their lipid-lowering effect
Food Bioscience ( IF 5.2 ) Pub Date : 2020-12-08 , DOI: 10.1016/j.fbio.2020.100836
Hui Yang , Wen Su , Junli Hua , Chuang Wang , Chaoyun Wang

Sixteen kinds of non-volatile fat-soluble substances were isolated from the Haihong fruit wine by organic solvent extraction and chromatographic techniques. The structures of 13 compounds were identified by means of mass spectrometry and nuclear magnetic resonance. The relationship between the pharmacological effects of Haihong fruit wine and its active substances such as hyperoside, rutin, catechin, epicatechin, and β-sitosterol was investigated. Results showed that the contents of hyperin, rutin, catechin, epicatechin, naringin dihydrochalcone, β-sterol and other polyphenol flavonoids in the Haihong fruit wine could significantly improve the lipid metabolism of hyperlipidemic mice, increase high-density lipoprotein, reduce blood viscosity, and significantly prevent platelet aggregation and fat accumulation in the liver of mice. The strong reduction and chelation of phenolic hydroxyl groups in hyperin, catechin and rutin are the essential reasons for the pharmacological effects of the fruit wine. These substances can exert their pharmacological effects by eliminating excess free radicals of ·DPPH, ·OH, and ·O2 and by complexing metal ion catalysts which are conducive to the formation of free radicals.



中文翻译:

海虹果酒中非挥发性物质及其降脂作用的研究

通过有机溶剂萃取和色谱技术从海虹果酒中分离出16种非挥发性脂溶性物质。通过质谱和核磁共振鉴定了13种化合物的结构。研究了海虹果酒的药理作用与其活性成分如高丝苷,芦丁,儿茶素,表儿茶素和β-谷固醇之间的关系。结果表明,海虹果酒中的高丝素,芦丁,儿茶素,表儿茶素,柚皮素二氢查尔酮,β-固醇和其他多酚类黄酮的含量可以显着改善高脂血症小鼠的脂质代谢,增加高密度脂蛋白,降低血液粘度,并显着防止小鼠肝脏中血小板聚集和脂肪积累。金丝桃素,儿茶素和芦丁中酚羟基的强烈还原和螯合是果酒具有药理作用的根本原因。这些物质可以通过消除·DPPH,·OH和·O的过量自由基发挥药理作用。2 -并且通过络合金属离子催化剂,其有利于自由基的形成。

更新日期:2020-12-11
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