Pseudomonas aeruginosa and Staphylococcus aureus are the two dominant Gram-negative and -positive species, respectively, isolated from patients with contact lens-related bacterial keratitis. The clinical features of bacterial keratitis vary, such that timely differential diagnosis can be challenging, which may cause a delay in diagnosis resulting in poorer outcome. This review aims to explore the current understanding of clinical and immunological features associated with contact lens-related P. aeruginosa and S. aureus keratitis based on currently available evidence.

Firstly, the review characterises contact lens-related P. aeruginosa and S. aureus keratitis, based on clinical features and prognostic factors. Secondly, the review describes the primary immune response associated with a bacterial infection in in-vivo non-scratch contact lens-wearing animal models, colonised by bacteria on contact lens and topical administration of bacteria on the cornea. Finally, the review discusses the role of macrophage inflammatory protein-2 (MIP-2) and intercellular adhesion molecule (ICAM-1) in neutrophil recruitment based on both in-vivo scratch models of bacterial keratitis and bacterial challenged in cell culture models.

铜绿假单胞菌和金黄色葡萄球菌是两种主要的革兰氏阴性菌和革兰氏阳性菌，分别从隐形眼镜相关细菌性角膜炎患者中分离出来。细菌性角膜炎的临床特征各不相同，因此及时鉴别诊断可能具有挑战性，这可能导致诊断延误，导致预后较差。本综述旨在根据现有证据，探讨目前对与隐形眼镜相关铜绿假单胞菌和金黄色葡萄球菌角膜炎相关的临床和免疫学特征的理解。

首先，该综述根据临床特征和预后因素对与隐形眼镜相关的铜绿假单胞菌和金黄色葡萄球菌角膜炎进行了表征。其次，该综述描述了与体内非刮擦隐形眼镜佩戴动物模型中细菌感染相关的主要免疫反应，这些动物模型被隐形眼镜上的细菌定植和角膜上细菌的局部给药。最后，该综述基于细菌性角膜炎的体内划痕模型和细胞培养模型中的细菌挑战，讨论了巨噬细胞炎症蛋白 2 (MIP-2) 和细胞间粘附分子 (ICAM-1) 在中性粒细胞募集中的作用。