To obtain nano-hydroxyapatite/poly(lactide-co-glycolide) (n-HA/PLGA) nanocomposite with superior mechanical properties, here, lignin was chosen to surface-modify for n-HA through co-precipitation method. The different reaction conditions of reaction time, phosphorus source, and the lignin addition amount were studied by fourier transformation infrared spectra, X-ray diffraction, the intuitionistic dispersion experiment, transmission electron microscope and thermal gravimetric analysis. The reaction mechanism and the best appropriate reaction condition were obtained. More importantly, the results of electromechanical universal tester, scanning electron microscope, differential scanning calorimetric analyzer, polarized optical microscopy and dynamic mechanical analysis confirmed that the obtained n-HA could greatly increase the mechanical strength of PLGA, owing to the excellent dispersion and promotion crystallization effect. Moreover, in vitro cell culture experimental results indicated that the n-HA surface-modified by lignin was favorable to improve the cell biocompatibility of PLGA. The study suggested that the introduction of lignin was a novel method to acquire a highly dispersed n-HA, which would provide a new idea to achieve the n-HA/PLGA nanocomposite as bone materials in future, and it would pave the way towards a new application of lignin in biomedical field.

为了获得具有优异机械性能的纳米羟基磷灰石/聚（丙交酯-共-乙交酯）（n-HA / PLGA）纳米复合材料，在这里，我们选择了木质素通过共沉淀法对n-HA进行表面改性。通过傅立叶变换红外光谱，X射线衍射，直觉分散实验，透射电镜和热重分析研究了反应时间，磷源和木质素添加量的不同反应条件。得到了反应机理和最适宜的反应条件。更重要的是，机电通用测试仪，扫描电子显微镜，差示扫描量热分析仪，偏光光学显微镜和动态力学分析证实，所得到的n-HA具有优异的分散和促进结晶作用，可以大大提高PLGA的机械强度。此外，体外细胞培养实验结果表明，木质素表面修饰的n-HA有利于提高PLGA的细胞生物相容性。研究表明，木质素的引入是一种获得高度分散的n-HA的新颖方法，这将为将来实现n-HA / PLGA纳米复合材料作为骨材料提供新的思路，并且将为木质素铺平道路。木质素在生物医学领域的新应用。