A facile and high-efficient synthesis of lingzhifuran A, a Smad3 phosphorylation inhibitor isolated from Ganoderma lucidum, was developed from commercially available dibenzo[b,d]furan. The crucial step of this strategy was achieved via condensation reaction using key intermediate 8-hydroxydibenzo[b,d]furan-4-carbaldehyde and commercially available (E)-2-methylbut-2-enal. By this strategy, lingzhifuran A was obtained in 5 steps with up to 57.6% yield.

中文翻译：

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缩合反应改进合成Smad3磷酸化抑制剂灵芝呋喃A

从市售的二苯并[ b ，d ]呋喃中开发了一种灵芝呋喃A的简便高效合成方法，该灵芝呋喃A是从灵芝分离的Smad3磷酸化抑制剂。该策略的关键步骤是通过使用关键中间体8-羟基二苯并[ b ，d ]呋喃-4-甲醛和可商购获得的（E ）-2-甲基丁-2-烯醛进行缩合反应实现的。通过该策略，分5步获得了灵芝呋喃A，收率高达57.6％。