Glioblastoma multiforme (GBM) continues as one of the most lethal cerebral cancers despite standard therapeutic modalities, such as maximum surgical resection and chemoradiation. The minimal effectiveness of existing therapies necessitates the development of additional drug candidates that could improve the prognosis of GBM patients. Accumulating evidence suggests that calcium (Ca²⁺) is involved in the processes of cell proliferation, metastasis, angiogenesis, migration, and invasiveness. Therefore, Ca²⁺ could serve as a crucial regulator of tumorigenesis and a potential treatment target in GBM. In this context, specific natural products are known to modulate Ca²⁺ signaling pathways implicated in tumor growth, apoptosis, angiogenesis, and development of GBM. Here, the focus is on the function of Ca²⁺ as a therapeutic target in GBM and reviewing certain natural products that affect the signaling pathways of Ca²⁺.

尽管有标准的治疗方式，例如最大程度的手术切除和化学放疗，多形胶质母细胞瘤（GBM）仍是最致命的脑癌之一。现有疗法的最小有效性需要开发可以改善GBM患者预后的其他候选药物。越来越多的证据表明，钙（Ca ²⁺）参与细胞增殖，转移，血管生成，迁移和侵袭性过程。因此，Ca ²⁺可以作为肿瘤发生的关键调节剂和GBM的潜在治疗靶标。在这种情况下，已知特定的天然产物可调节Ca ²⁺信号通路与GBM的肿瘤生长，凋亡，血管生成和发育有关。在这里，重点是Ca ²⁺作为GBM中的治疗靶标的功能，并综述某些影响Ca ²⁺信号传导途径的天然产物。