The Zika virus (ZIKV) infection is a major public health concern in Brazil and worldwide, being a rapidly spreading disease with possible severe complications for pregnant women and neonates. There is currently no preventative therapy or specific treatment available. Within this context, drug repositioning is a very promising approach for the discovery of new treatment compounds, since old drugs may become new ones. Therefore, this paper aims to perform a literature mini-review to identify promising compounds to combat this virus. The mechanism of action at the molecular level and the structure-activity relationship of prototypes are discussed. Among the candidates identified, we highlight sofosbuvir, chloroquine and suramin, which present a greater quantity of experimental data to draw on for our discussion. The current treatment is palliative; therefore, this study is of paramount importance in identifying drug candidates useful for combating ZIKV.

寨卡病毒（ZIKV）感染是巴西乃至全世界的主要公共卫生问题，是一种正在迅速传播的疾病，可能对孕妇和新生儿产生严重的并发症。当前没有预防性疗法或特定的治疗方法。在这种情况下，重新定位药物是发现新治疗化合物的非常有前途的方法，因为旧药物可能会成为新药物。因此，本文旨在进行文献综述，以确定有希望的化合物来对抗这种病毒。讨论了在分子水平上的作用机理以及原型的构效关系。在确定的候选人中，我们重点介绍了索非布韦，氯喹和苏拉明，它们提供了大量实验数据供我们讨论。目前的治疗是姑息治疗；