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Cytokine Polymorphisms and Predisposition to Diabetic Nephropathy: A Meta-Analysis
International Archives of Allergy and Immunology ( IF 2.8 ) Pub Date : 2020-12-07 , DOI: 10.1159/000510250
Suqin Wang 1 , Jiazhi Dong 2 , Lingling Huang 3
Affiliation  

Background: Cytokine polymorphismsmight influence the predisposition to diabetic nephropathy (DN), but the results of already published related studies are still controversial and ambiguous. Objectives: The authors designed this meta-analysis to more precisely estimate relationships between TNF-α/IL-1/IL-4/IL-8/IL-18polymorphisms and DN by pooling the results of already published related studies. Methods: The authors searched Pubmed, Embase, Web of Science and CNKI for already published studies. Thirty already published studies were pooled and analyzed in this meta-analysis. Results: The overall pooled meta-analysis results showed that distributions of TNF-α –238 G/A, TNF-α –308 G/A, TNF-α –1031 C/T, IL-1A −889 C/T, IL-1B −511 C/Tand IL-18 –137 G/C polymorphisms among patients and controls differed significantly. Additionally, we also found that distributions of TNF-α –308 G/A, IL-1B −511 C/T and IL-18 –137 G/C polymorphisms among patients and controls from Asians differed significantly, and the distribution of the IL-1B −511 C/T polymorphism among patients and controls from Caucasians also differed significantly. Conclusion: The meta-analysis results demonstrated that TNF-α –238 G/A, TNF-α –308 G/A, TNF-α –1031 C/T, IL-1A −889 C/T, IL-1B −511 C/Tand IL-18 –137 G/Cpolymorphisms might influence predisposition to DN in the overall pooled population. Moreover, TNF-α –308 G/A, IL-1B −511 C/T and IL-18 –137 G/C polymorphisms might influence predisposition to DN in Asians, whereas the IL-1B −511 C/T polymorphism might also influence predisposition to DN in Caucasians.
Int Arch Allergy Immunol


中文翻译:

细胞因子多态性和糖尿病肾病的易感性:荟萃分析

背景:细胞因子多态性可能会影响糖尿病肾病(DN)的易感性,但已发表的相关研究结果仍存在争议和模棱两可。目标:作者设计了这项荟萃分析,通过汇集已发表的相关研究的结果,更精确地估计TNF-α/IL-1/IL-4/IL-8/IL-18多态性与 DN 之间的关系。方法:作者在 Pubmed、Embase、Web of Science 和 CNKI 中搜索已发表的研究。在这项荟萃分析中汇总和分析了 30 项已发表的研究。结果:总体汇总的荟萃分析结果显示TNF-α –238 G/A、TNF-α –308 G/A、TNF-α 的分布–1031 C/T, IL-1A -889 C/T, IL-1B -511 C/TIL-18 –137 G/C 多态性在患者和对照之间存在显着差异。此外,我们还发现亚洲人患者和对照中TNF-α – 308 G/A、IL-1B –511 C/T 和IL-18 –137 G/C 多态性的分布存在显着差异,IL -1B -511 C/T 多态性在来自白种人的患者和对照之间也存在显着差异。结论:荟萃分析结果表明,TNF-α –238 G/A、TNF-α –308 G/A、TNF-α –1031 C/T、IL-1A -889 C/T、IL-1B -511货到付款IL-18 –137 G/C多态性可能会影响整个合并人群中对 DN 的易感性。此外,TNF-α – 308 G/A、IL-1B -511 C/T 和IL-18 –137 G/C 多态性可能会影响亚洲人对 DN 的易感性,而IL-1B -511 C/T 多态性也可能会影响亚洲人对 DN 的易感性。影响白种人对 DN 的倾向。
Int Arch 过敏免疫
更新日期:2020-12-07
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