The phospholipid composition of lipoproteins is determined by the specificity of hepatic phospholipid biosynthesis. Plasma phospholipid 20:4n‐6 and 22:6n‐3 concentrations are higher in women than in men. We used this sex difference in a lipidomics analysis of the impact of endocrine factors on the phospholipid class and molecular species composition of fasting plasma from young men and women. Diester species predominated in all lipid classes measured. 20/54 Phosphatidylcholine (PtdCho) species were alkyl ester, 15/48 phosphatidylethanolamine (PtdEtn) species were alkyl ester, and 12/48 PtdEtn species were alkenyl ester. There were no significant differences between sexes in the proportions of alkyl PtdCho species. The proportion of alkyl ester PtdEtn species was greater in women than men, while the proportion of alkenyl ester PtdEtn species was greater in men than women. None of the phosphatidylinositol (PtdIns) or phosphatidylserine (PtdSer) molecular species contained ether‐linked fatty acids. The proportion of PtdCho16:0_22:6, and the proportions of PtdEtn O‐16:0_20:4 and PtdEtn O‐18:2_20:4 were greater in women than men. There were no sex differences in PtdIns and PtdSer molecular species compositions. These findings show that plasma phospholipids can be modified by sex. Such differences in lipoprotein phospholipid composition could contribute to sexual dimorphism in patterns of health and disease.

中文翻译：

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健康男性和女性血浆的脂质组学分析表明，两性之间的磷脂类别和分子种类存在差异

脂蛋白的磷脂组成由肝磷脂生物合成的特异性决定。女性的血浆磷脂 20:4n-6 和 22:6n-3 浓度高于男性。我们在脂质组学分析中使用了这种性别差异，分析内分泌因素对年轻男性和女性空腹血浆的磷脂类别和分子种类组成的影响。在测量的所有脂质类别中，二酯种类占主导地位。20/54 磷脂酰胆碱 (PtdCho) 物质是烷基酯，15/48 磷脂酰乙醇胺 (PtdEtn) 物质是烷基酯，12/48 PtdEtn 物质是链烯基酯。在烷基 PtdCho 物种的比例上，性别之间没有显着差异。烷基酯 PtdEtn 物种的比例在女性中高于男性，而烯基酯 PtdEtn 物种的比例在男性中高于女性。磷脂酰肌醇 (PtdIns) 或磷脂酰丝氨酸 (PtdSer) 分子种类均不含醚连接的脂肪酸。PtdCho16:0_22:6、PtdEtn O-16:0_20:4和PtdEtn O-18:2_20:4的比例在女性中高于男性。PtdIns 和 PtdSer 分子种类组成没有性别差异。这些发现表明血浆磷脂可以通过性别进行修饰。脂蛋白磷脂组成的这种差异可能导致健康和疾病模式的性别二态性。4 和 PtdEtn O-18:2_20:4 在女性中高于男性。PtdIns 和 PtdSer 分子种类组成没有性别差异。这些发现表明血浆磷脂可以通过性别进行修饰。脂蛋白磷脂组成的这种差异可能导致健康和疾病模式的性别二态性。4 和 PtdEtn O-18:2_20:4 在女性中高于男性。PtdIns 和 PtdSer 分子种类组成没有性别差异。这些发现表明血浆磷脂可以通过性别进行修饰。脂蛋白磷脂组成的这种差异可能导致健康和疾病模式的性别二态性。