Over the past decades, polymer mechanochemistry has focused on the development and application of advanced force application methods to better understand the mechanochemical response of mechanophores. In this regard, techniques such as ultrasonication and single‐molecule force spectroscopy (SMFS) are used to activate and detect up to thousands of chemical events within a polymer single chain, allowing the researchers to probe the mechanochemical reactivity of these stress‐responsive motifs. Here, the most recent contributions of the single‐molecule force spectroscopy technique to this field are presented, putting emphasis on the fundamental parameters of the technique for triggering specific force responses and on the description of force–extension curves measured for single‐ and multi‐mechanophore polymers. Moreover, new contributions of microscopy‐based techniques in the field of polymer mechanochemistry, as well as the potential application of single‐chain nanoparticles as mechanoresponsive materials, are highlighted.

中文翻译：

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纳米级的触发力：单链机械激活和操纵技术

在过去的几十年中，高分子机械化学一直致力于先进的力施加方法的开发和应用，以更好地理解机械体的机械化学反应。在这方面，超声和单分子力谱（SMFS）等技术可用于激活和检测聚合物单链中多达数千个化学事件，从而使研究人员能够探索这些应激反应性基序的机械化学反应性。此处介绍了单分子力谱技术在该领域的最新贡献，重点介绍了用于触发特定力响应的技术的基本参数，以及对针对单分子力和多分子力测得的力-延伸曲线的描述。力学聚合物。此外，