Hemorrhagic shock (HS) is a medical emergency during trauma. Significant loss of tissue perfusion may result in cellular hypoxia, organ damage and death. The primary treatment of HS is control of the source of bleeding as soon as possible and fluid replacement (crystalloid solutions and blood transfusion). Metabolomics can identify novel biomarkers for various functional and organic diseases. Therefore, systematic exploration of the biological mechanisms of HS and blood transfusion enables the optimization of treatments for HS to reduce the occurrence of organ damage. In this study, a global metabolic profiling strategy is applied to evaluate metabolic changes in the HS rat model. A serum metabolic network with 58 significant metabolites was constructed for HS and resuscitation. Our investigation will offer insights into the pathogenesis.

中文翻译：

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失血性休克和复苏的整体代谢图谱

失血性休克（HS）是创伤期间的医疗急症。组织灌注的显着丧失可能导致细胞缺氧，器官损伤甚至死亡。HS的主要治疗方法是尽快控制出血源和补液（晶体溶液和输血）。代谢组学可以识别各种功能性和器质性疾病的新型生物标志物。因此，对HS和输血生物学机制的系统性探索可以优化HS的治疗方法，以减少器官损伤的发生。在这项研究中，全球代谢谱分析策略被应用于评估HS大鼠模型中的代谢变化。建立了具有58种重要代谢物的血清代谢网络，用于HS和复苏。我们的研究将提供有关发病机理的见解。