Changes in the abundance of protein and RNA molecules can impair the formation of complexes in the cell leading to toxicity and death. Here we exploit the information contained in protein, RNA and DNA interaction networks to provide a comprehensive view of the regulation layers controlling the concentration‐dependent formation of assemblies in the cell. We present the emerging concept that RNAs can act as scaffolds to promote the formation ribonucleoprotein complexes and coordinate the post‐transcriptional layer of gene regulation. We describe the structural and interaction network properties that characterize the ability of protein and RNA molecules to interact and phase separate in liquid‐like compartments. Finally, we show that presence of structurally disordered regions in proteins correlate with the propensity to undergo liquid‐to‐solid phase transitions and cause human diseases. Also see the video abstract here https://youtu.be/kfpqibsNfS0

中文翻译：

---

RNA-蛋白质相互作用：协调调节网络的核心参与者

蛋白质和 RNA 分子丰度的变化会损害细胞中复合物的形成，从而导致毒性和死亡。在这里，我们利用蛋白质、RNA 和 DNA 相互作用网络中包含的信息来全面了解控制细胞中组装的浓度依赖性形成的调节层。我们提出了一个新兴的概念，即 RNA 可以作为支架来促进核糖核蛋白复合物的形成并协调基因调控的转录后层。我们描述了表征蛋白质和 RNA 分子在液体状隔室中相互作用和相分离的能力的结构和相互作用网络特性。最后，我们表明，蛋白质中结构无序区域的存在与经历液固相变并导致人类疾病的倾向相关。另请参阅此处的视频摘要 https://youtu.be/kfpqibsNfS0