ABSTRACT

Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE, PRRC2A (aka BAT2), and SKIV2L, encode RNA-binding proteins with clear roles in post-transcriptional gene regulation and RNA surveillance. These genes are likely to have important functions in immunity and are associated with autoimmune diseases.

中文翻译：

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MHC III 类 RNA 结合蛋白和免疫

摘要

在这里，我们回顾了表明 RNA 结合蛋白在脊椎动物免疫中的作用的数据。我们专注于在主要组织相容性复合体的 III 类区域中发现的基因产物。其中六个基因，DDX39B（又名 BAT1）、DXO、LSM2、NELFE、PRRC2A（又名 BAT2）和 SKIV2L，编码 RNA 结合蛋白，在转录后基因调控和 RNA 监视中具有明确的作用。这些基因很可能在免疫中具有重要功能，并与自身免疫性疾病有关。