ABSTRACT Vitamin D deficiency and a high-fat diet are considered health problems worldwide. The aims of this study were to examine the prevalence of vitamin D deficiency/insufficiency in young adults, factors related to the vitamin D status, and the influence of vitamin D deficiency and/or a high-fat diet on bone parameters. Here, we investigated the hypothesis that a high-fat diet in the presence of a vitamin D-deficient status would have a more negative influence on bone parameters than a normal-fat diet with such a status. In the present study, we targeted young Japanese adults aged 21-23 (n=175). We conducted a diet survey based on 3-day food records, biochemical examination of serum, and quantitative ultrasound (QUS) measurements at the calcaneus. As a result, the rates of vitamin D deficiency {serum 25-hydroxyvitamin D3 [25(OH)D] concentration less than 20 ng/mL} and insufficiency [serum 25(OH)D concentration less than 30 ng/mL but not less than 20 ng/mL] were 60.6 and 30.9%, respectively. A positive correlation was observed between the serum 25(OH)D level and serum bone-specific alkaline phosphatase (ALP) level, which is a serum marker of bone formation (r=0.253, p

中文翻译：

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缺乏维生素 D 的高脂肪饮食对年轻人跟骨定量超声参数有负面影响：一项横断面研究

摘要 维生素 D 缺乏和高脂肪饮食被认为是世界范围内的健康问题。本研究的目的是检查年轻人维生素 D 缺乏/不足的患病率、与维生素 D 状态相关的因素，以及维生素 D 缺乏和/或高脂肪饮食对骨骼参数的影响。在这里，我们研究了这样一个假设，即在维生素 D 缺乏状态下的高脂肪饮食比具有这种状态的正常脂肪饮食对骨骼参数有更大的负面影响。在本研究中，我们针对 21-23 岁的日本年轻人 (n=175)。我们根据 3 天的食物记录、血清生化检查和跟骨的定量超声 (QUS) 测量进行了饮食调查。其结果，维生素 D 缺乏率{血清 25-羟基维生素 D3 [25(OH)D] 浓度低于 20 ng/mL}和不足率[血清 25(OH)D 浓度低于 30 ng/mL 但不低于 20 ng/ mL] 分别为 60.6% 和 30.9%。血清 25(OH)D 水平与血清​​骨特异性碱性磷酸酶 (ALP) 水平呈正相关，这是骨形成的血清标志物 (r=0.253, p