Tooth and bone are independent tissues with a close relationship. Both are composed of a highly calcified outer structure and soft inner tissue, and both are constantly under mechanical stress. In particular, the alveolar bone and tooth constitute an occlusion system and suffer from masticatory and occlusal force. Thus, mechanotransduction is a key process in many developmental, physiological and pathological processes in tooth and bone. Mechanosensitive ion channels such as Piezo1 and Piezo2 are important participants in mechanotransduction, but their functions in tooth and bone are poorly understood. This review summarizes our current understanding of mechanosensitive ion channels and their roles in tooth and bone tissues. Research in these areas may shed new light on the regulation of tooth and bone tissues and potential treatments for diseases affecting these tissues.

牙齿和骨骼是关系密切的独立组织。两者都由高度钙化的外部结构和柔软的内部组织组成，并且都始终处于机械应力之下。特别是牙槽骨和牙齿构成咬合系统，受到咀嚼和咬合力的影响。因此，机械转导是牙齿和骨骼中许多发育、生理和病理过程的关键过程。Piezo1 和 Piezo2 等机械敏感离子通道是机械传导的重要参与者，但它们在牙齿和骨骼中的功能却知之甚少。这篇综述总结了我们目前对机械敏感离子通道及其在牙齿和骨组织中的作用的理解。