Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with chronic abdominal pain and altered pain processing. The aim of this study was to examine whether attentional processes contribute to altered pain inhibition processes in patients with IBS. Nine female patients with IBS and nine age-/sex-matched controls were included in a pain inhibition paradigm using counter-stimulation and distraction with electroencephalography. Patients with IBS showed no inhibition of pain-related brain activity by heterotopic noxious counter-stimulation (HNCS) or selective attention. In the control group, HNCS and selective attention decreased the N100, P260 and high-gamma oscillation power. In addition, pain-related high-gamma power in sensorimotor, anterior cingulate and left dorsolateral prefrontal cortex was decreased by HNCS and selective attention in the control group, but not in patients with IBS. These results indicate that the central pain inhibition deficit in IBS reflects interactions between several brain processes related to pain and attention.

中文翻译：

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注意力对肠易激综合征患者疼痛抑制过程改变的贡献的电生理研究

肠易激综合征 (IBS) 是一种与慢性腹痛和疼痛处理改变相关的功能性胃肠道疾病。本研究的目的是检查注意力过程是否有助于改变 IBS 患者的疼痛抑制过程。九名患有 IBS 的女性患者和九名年龄/性别匹配的对照被包括在使用反刺激和脑电图分散注意力的疼痛抑制范式中。IBS 患者没有表现出异位有害反刺激 (HNCS) 或选择性注意对疼痛相关大脑活动的抑制。在对照组中，HNCS 和选择性注意降低了 N100、P260 和高伽马振荡功率。此外，感觉运动中与疼痛相关的高伽马功率，前扣带回和左背外侧前额叶皮层在对照组中被 HNCS 和选择性注意减少，但在 IBS 患者中没有。这些结果表明，IBS 的中枢疼痛抑制缺陷反映了与疼痛和注意力相关的几个大脑过程之间的相互作用。