High-fat diet (HFD) can induce deficits in neural function, oxidative stress, and decrease hippocampal neurogenesis. Hypericum ( H. ) scabrum extract (Ext) contains compounds that could treat neurological disorders. This study aimed to examine the neuroprotective impacts of the H. scabrum Ext on hippocampal synaptic plasticity in rats that were fed HFD. Fifty-four male Wistar rats (220 ± 10 g) were randomly arranged in six groups: (1) HFD group; (2) HFD + Ext300 group; (3) HFD + Ext100 group; (4) Control group; (5) Ext 300 mg/kg group; (6) Ext 100 mg/kg group. These protocols were administrated for 3 months. After this stage, a stimulating electrode was implanted in the perforant pathway (PP), and a bipolar recording electrode was embedded into the dentate gyrus (DG). Long-term potentiation (LTP) was provoked by high-frequency stimulation (HFS) of the PP. Field excitatory postsynaptic potentials (EPSP) and population spikes (PS) were recorded at 5, 30, and 60 min after HFS. The HFD group exhibited a large and significant decrease in their PS amplitude and EPSP slope as compared to the control and extract groups. In reverse, H. scabrum administration in the HFD + Ext rats reversed the effect of HFD on the PS amplitude and EPSP slope. The results of the study support that H. scabrum Ext can inhibit diminished synaptic plasticity caused by the HFD. These effects are probably due to the extreme antioxidant impacts of the Ext and its capability to scavenge free radicals.

中文翻译：

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的影响 金丝桃scabrum 在高脂肪饮食喂养的大鼠上齿状回提取物突触可塑性

高脂饮食（HFD）可以诱发神经功能缺陷，氧化应激并减少海马神经发生。 金丝桃 （ H. ） ab 提取物（Ext）含有可以治疗神经系统疾病的化合物。这项研究旨在检查 sc疮 的神经保护作用 补充高脂饮食对大鼠海马突触可塑性的影响。将54只Wistar大鼠（220±10 g）随机分为6组：（1）HFD组；（2）HFD + Ext300组；（3）HFD + Ext100组；（4）对照组；（5）Ext 300 mg / kg组；（6）Ext 100 mg / kg组。这些协议已进行了3个月的管理。在此阶段之后，将刺激电极植入穿孔通路（PP）中，并将双极记录电极嵌入齿状回（DG）中。PP的高频刺激（HFS）引起了长期增强（LTP）。在HFS后第5、30和60分钟记录了田间兴奋性突触后电位（EPSP）和种群高峰（PS）。与对照组和提取物组相比，HFD组的PS振幅和EPSP斜率显着大幅度下降。相反， 在HFD + Ext大鼠中施用 H. scabrum可 逆转HFD对PS振幅和EPSP斜率的影响。该研究结果支持support 疮Ex。 可以抑制由HFD引起的突触可塑性下降。这些影响可能是由于Ext的极端抗氧化剂影响及其清除自由基的能力所致。