The aim of study was to compare patients with hypertrophic cardiomyopathy divided according to septal configuration assessed in a 4-chamber apical window. The study group consisted of 56 consecutive patients. Reversed septal curvature (RSC) and non-RSC were diagnosed in 17 (30.4%) and 39 (69.6%) patients, respectively. Both RSC and non-RSC groups were compared in terms of the level of high-sensitivity troponin I (hs-TnI), NT-proBNP (absolute value), NT-proBNP/ULN (value normalized for sex and age), and echocardiographic parameters, including left ventricular outflow tract gradient (LVOTG). A higher level of hs-TnI was observed in RSC patients as compared to the non-RSC group (102 (29.2-214.7) vs. 8.7 (5.3-18) (ng/l), ). A trend toward increased NT-proBNP value was reported in RSC patients (1279 (367.3-1186) vs. 551.7 (273-969) (pg/ml), ). However, no difference in the NT-proBNP/ULN level between both groups was observed. Provocable LVOTG was higher in RSC as compared to non-RSC patients (51 (9.5-105) vs. 13.6 (7.5-31) (mmHg), ). Furthermore, more patients with RSC had prognostically unfavourable increased septal thickness to left LV diameter at the end diastole ratio. Patients with RSC were associated with an increased level of hs-TnI, and the only trend observed in this group was for the higher NT-proBNP levels. RSC seems to be an alerting factor for the risk of ischemic events. Not resting but only provocable LVOTG was higher in RSC as compared to non-RSC patients.

中文翻译：

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在肥厚型心肌病中，扭转的室间隔弯曲与肌钙蛋白水平升高有关

研究的目的是比较肥厚型心肌病患者，根据在 4 腔心尖窗中评估的间隔配置进行划分。研究组由 56 名连续患者组成。分别有 17 名 (30.4%) 和 39 名 (69.6%) 患者被诊断为室间隔反向弯曲 (RSC) 和非 RSC。比较 RSC 组和非 RSC 组的高敏肌钙蛋白 I (hs-TnI)、NT-proBNP（绝对值）、NT-proBNP/ULN（按性别和年龄标准化的值）和超声心动图的水平参数，包括左心室流出道梯度 (LVOTG)。与非 RSC 组相比，在 RSC 患者中观察到更高水平的 hs-TnI（102 (29.2-214.7) vs. 8.7 (5.3-18) (ng/l)，）。在 RSC 患者中报告了 NT-proBNP 值增加的趋势（1279 (367.3-1186) vs. 551.7 (273-969) (pg/ml)，）。然而，没有观察到两组之间 NT-proBNP/ULN 水平的差异。与非 RSC 患者相比，RSC 中可激发的 LVOTG 更高（51 (9.5-105) vs. 13.6 (7.5-31) (mmHg)，）。此外，更多的 RSC 患者在舒张末期比左室间隔厚度增加对预后不利。RSC 患者与 hs-TnI 水平升高有关，在该组中观察到的唯一趋势是 NT-proBNP 水平升高。RSC 似乎是缺血事件风险的警示因素。与非 RSC 患者相比，RSC 中未休息但仅可激发的 LVOTG 更高。