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Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood
Nutrition Research ( IF 4.5 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.nutres.2020.12.005 Jean Golding 1 , Steven Gregory 1 , Rosie Clark 1 , Yasmin Iles-Caven 1 , Genette Ellis 1 , Caroline M Taylor 1 , Joseph Hibbeln 2
Nutrition Research ( IF 4.5 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.nutres.2020.12.005 Jean Golding 1 , Steven Gregory 1 , Rosie Clark 1 , Yasmin Iles-Caven 1 , Genette Ellis 1 , Caroline M Taylor 1 , Joseph Hibbeln 2
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Abstract Deficiencies of many nutrients in pregnancy have adverse effects on fetal brain development with consequent impaired cognitive function in childhood. However, it is unclear whether deficiencies of vitamin B12 prenatally are harmful to the developing fetus. We therefore used the Avon Longitudinal Study of Parents and Children to test the hypothesis that cognitive outcomes in childhood are reduced if their mothers consumed a diet low in vitamin B12 during pregnancy. A detailed exposome analysis was used to identify nine factors independently associated with low vitamin B12 intake. These were taken into account in each of 26 outcome analyses. Results showed that the children of women with the lowest 10% intake of B12 were at increased risk of poor vocabulary at 24 months, reduced ability at combining words at 38 months, poor speech intelligibility at 6 years, poor mathematics comprehension at school years 4 and 6 (ages 8-9 and 10-11 years), and poor results on the national mathematics tests (age 13). There were no such significant adjusted associations for reading or spelling abilities, or for verbal or full-scale IQ (Intelligence Quotient) at 8 or at 15. Thus, we have confirmed that there are adverse effects on the child's development if the pregnant woman has a low intake of vitamin B12, and we have shown that these are specific to certain speech and mathematical abilities.
中文翻译:
母亲产前维生素 B12 的摄入与儿童时期的语言发育和数学能力有关
摘要 妊娠期多种营养素缺乏对胎儿大脑发育产生不利影响,从而导致儿童期认知功能受损。然而,尚不清楚产前缺乏维生素 B12 是否对发育中的胎儿有害。因此,我们使用雅芳父母和儿童纵向研究来检验如果母亲在怀孕期间食用维生素 B12 含量低的饮食会降低儿童时期认知结果的假设。详细的暴露分析用于确定与低维生素 B12 摄入量独立相关的九个因素。在 26 项结果分析中均考虑了这些因素。结果表明,维生素 B12 摄入量最低 10% 的女性的孩子在 24 个月时词汇量较差的风险增加,在 38 个月时组合单词的能力降低,6 岁时语言清晰度较差,4 岁和 6 岁(8-9 岁和 10-11 岁)数学理解较差,国家数学考试成绩较差(13 岁)。在 8 岁或 15 岁时,阅读或拼写能力、言语或全面智商(智商)没有如此显着的调整关联。因此,我们已经证实,如果孕妇有维生素 B12 摄入量低,我们已经证明这些维生素 B12 是特定于某些语言和数学能力的。
更新日期:2021-02-01
中文翻译:
母亲产前维生素 B12 的摄入与儿童时期的语言发育和数学能力有关
摘要 妊娠期多种营养素缺乏对胎儿大脑发育产生不利影响,从而导致儿童期认知功能受损。然而,尚不清楚产前缺乏维生素 B12 是否对发育中的胎儿有害。因此,我们使用雅芳父母和儿童纵向研究来检验如果母亲在怀孕期间食用维生素 B12 含量低的饮食会降低儿童时期认知结果的假设。详细的暴露分析用于确定与低维生素 B12 摄入量独立相关的九个因素。在 26 项结果分析中均考虑了这些因素。结果表明,维生素 B12 摄入量最低 10% 的女性的孩子在 24 个月时词汇量较差的风险增加,在 38 个月时组合单词的能力降低,6 岁时语言清晰度较差,4 岁和 6 岁(8-9 岁和 10-11 岁)数学理解较差,国家数学考试成绩较差(13 岁)。在 8 岁或 15 岁时,阅读或拼写能力、言语或全面智商(智商)没有如此显着的调整关联。因此,我们已经证实,如果孕妇有维生素 B12 摄入量低,我们已经证明这些维生素 B12 是特定于某些语言和数学能力的。