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Restoration of BMI1 levels after the administration of early harvest extra virgin olive oil as a therapeutic strategy against Alzheimer's disease
Experimental Gerontology ( IF 3.9 ) Pub Date : 2020-12-05 , DOI: 10.1016/j.exger.2020.111178
Elena E. Tzekaki , Angelos Papaspyropoulos , Magda Tsolaki , Eftychia Lazarou , Mahi Kozori , Αnastasia A. Pantazaki

Even though Alzheimer's disease (AD) is the most common cause of dementia, the mechanisms governing the establishment and progression of the disease remain largely unknown. Here, we investigated the implication of the neuroprotective protein BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) in AD and the possibility to reverse the onset of the disease through the administration of extra virgin olive oil (EVOO) in Mild Cognitive Impairment (MCI) patients. For this purpose, we utilized a wide bank of MCI patient samples to examine the potential effects of EVOO. We found that while EVOO treatment increases BMI1 levels, p53 levels drop in MCI patient serum after EVOO treatment for 12 months. Additionally, AD-related biomarkers (p-tau, Aβ1–42 and Aβ1–42/Aβ-40 ratio) return to normal levels after administration of EVOO in MCI patients for 12 months. Moreover, we show that upon EVOO administration, BMI1-upregulation correlates with reduction of oxidative stress and inflammatory responses. In conclusion, we provide clinical trial evidence to confirm that restoration of BMI1 activity through EVOO administration in MCI patients constitutes a potential therapeutic approach against neurodegeneration leading to AD.



中文翻译:

给予早期收获的特级初榨橄榄油后恢复BMI1水平可作为对抗阿尔茨海默氏病的治疗策略

尽管阿尔茨海默氏病(AD)是痴呆症最常见的病因,但控制该病的发生和发展的机制仍然未知。在这里,我们研究了神经保护蛋白BMI1(B淋巴瘤Mo-MLV插入区1同源物)在AD中的含义,以及通过在轻度认知障碍中施用特级初榨橄榄油(EVOO)来逆转疾病发作的可能性( MCI)患者。为此,我们利用了大量的MCI患者样本来检查EVOO的潜在作用。我们发现,尽管EVOO治疗可增加BMI1水平,但EVOO治疗12个月后,MCI患者血清中的p53水平下降。此外,与AD有关的生物标志物(p-tau,在MCI患者中服用EVOO后12个月,Aβ1-42和Aβ1-42/Aβ-40比值恢复正常。此外,我们表明在EVOO给药后,BMI1上调与氧化应激和炎症反应的减少有关。总之,我们提供了临床试验证据,以证实通过EVOO给药对MCI患者恢复BMI1活性构成了针对导致AD的神经退行性变的潜在治疗方法。

更新日期:2020-12-05
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