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Can biomechanical analysis shed some light on aneurysmal pathophysiology? Preliminary study on ex vivo cerebral arterial walls
Clinical Biomechanics ( IF 1.8 ) Pub Date : 2020-12-05 , DOI: 10.1016/j.clinbiomech.2020.105184
L. Brunasso , G. Alotta , M. Zingales , D.G. Iacopino , F. Graziano

Background

The pathophysiology of cerebral aneurysm is complex and poorly understood, and it can have the most catastrophic clinical presentation. Flow dynamics is a key player in the initiation and progression of aneurysm. Better understanding the interaction between hemodynamic loading and biomechanical wall responses can help to add the missing piece on aneurysmal pathophysiology. In this laboratory study we aimed to analyze the effect of the application of a mechanical force to cerebral arterial walls.

Methods

Displacement control tests were performed on five porcine cerebral arteries. The test machine was the T150 Nanotensile. The stiffness variation with the increment of the strain level is modeled as the outcome of an isotropic hyperelastic material model.

Findings

Through the application of an axial force we obtained Stress/Strain curves that showed a marked isotropic hyperelastic behavior, characterized by an increasing of stiffness with the level of strain. This behavior of the cerebral arterial wall is different from the well-established behavior of other arterial vessel (as the aortic vessel) characterized by a marked anisotropic behavior. Additionally, the data scattering observed for higher values of the applied stress are related to different individual packing of collagen fibers that represent the load-bearing mechanics at higher level of the strain.

Interpretation

The data obtained by test in this paper represent a first step in our ongoing research about the mechanics of multi-axial loads on cerebral arterial walls, and in producing more comprehensive patient-specific calculations for potential applications on cerebral aneurysm management.



中文翻译:

生物力学分析能否为动脉瘤的病理生理学提供一些启示?体外脑动脉壁的初步研究

背景

脑动脉瘤的病理生理学很复杂,人们对它的了解还很少,它可能具有最灾难性的临床表现。血流动力学是动脉瘤发生和发展的关键因素。更好地了解血流动力学负荷与生物力学壁反应之间的相互作用可以帮助增加动脉瘤病理生理学上的缺失部分。在此实验室研究中,我们旨在分析对脑动脉壁施加机械力的效果。

方法

在五个猪脑动脉上进行了位移控制测试。测试机器是T150纳米拉伸机。刚度随应变水平的增加而变化的模型是各向同性超弹性材料模型的结果。

发现

通过施加轴向力,我们获得了应力/应变曲线,该曲线显示出明显的各向同性超弹性行为,其特征是随着应变水平的增加,刚度增加。脑动脉壁的这种行为不同于以明显的各向异性行为为特征的其他动脉血管(作为主动脉血管)的公认行为。另外,对于较高的施加应力值观察到的数据散射与胶原纤维的不同单个堆积有关,这些胶原纤维代表了较高应变水平下的承载力学。

解释

本文通过测试获得的数据代表了我们正在进行的有关脑动脉壁多轴负荷力学研究的第一步,并为针对脑动脉瘤管理的潜在应用提供了更全面的针对患者的计算方法。

更新日期:2020-12-10
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