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The critical role of endothelial function in fine particulate matter-induced atherosclerosis
Particle and Fibre Toxicology ( IF 10 ) Pub Date : 2020-12-04 , DOI: 10.1186/s12989-020-00391-x
Shuang Liang 1, 2 , Jingyi Zhang 1, 2 , Ruihong Ning 1, 2 , Zhou Du 1, 2 , Jiangyan Liu 1, 2 , Joe Werelagi Batibawa 1, 2 , Junchao Duan 1, 2 , Zhiwei Sun 1, 2
Affiliation  

Ambient and indoor air pollution contributes annually to approximately seven million premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In particular, fine particulate matter (PM2.5) plays a major mortality risk factor particularly on cardiovascular diseases through mechanisms of atherosclerosis, thrombosis and inflammation. A review on the PM2.5-induced atherosclerosis is needed to better understand the involved mechanisms. In this review, we summarized epidemiology and animal studies of PM2.5-induced atherosclerosis. Vascular endothelial injury is a critical early predictor of atherosclerosis. The evidence of mechanisms of PM2.5-induced atherosclerosis supports effects on vascular function. Thus, we summarized the main mechanisms of PM2.5-triggered vascular endothelial injury, which mainly involved three aspects, including vascular endothelial permeability, vasomotor function and vascular reparative capacity. Then we reviewed the relationship between PM2.5-induced endothelial injury and atherosclerosis. PM2.5-induced endothelial injury associated with inflammation, pro-coagulation and lipid deposition. Although the evidence of PM2.5-induced atherosclerosis is undergoing continual refinement, the mechanisms of PM2.5-triggered atherosclerosis are still limited, especially indoor PM2.5. Subsequent efforts of researchers are needed to improve the understanding of PM2.5 and atherosclerosis. Preventing or avoiding PM2.5-induced endothelial damage may greatly reduce the occurrence and development of atherosclerosis.

中文翻译:

内皮功能在细颗粒物诱发的动脉粥样硬化中的关键作用

环境和室内空气污染每年导致约七百万人过早死亡。空气污染是气体和颗粒物质的复杂混合物。特别是,细颗粒物 (PM2.5) 通过动脉粥样硬化、血栓形成和炎症机制发挥着主要的死亡风险因素,尤其是心血管疾病。需要对 PM2.5 引起的动脉粥样硬化进行综述,以更好地了解所涉及的机制。在这篇综述中,我们总结了 PM2.5 诱导的动脉粥样硬化的流行病学和动物研究。血管内皮损伤是动脉粥样硬化的重要早期预测因子。PM2.5 诱导动脉粥样硬化机制的证据支持对血管功能的影响。由此,我们总结了PM2.5引发血管内皮损伤的主要机制,主要涉及血管内皮通透性、血管舒缩功能和血管修复能力三个方面。然后我们综述了PM2.5引起的内皮损伤与动脉粥样硬化的关系。PM2.5 诱导的内皮损伤与炎症、促凝血和脂质沉积相关。尽管PM2.5诱发动脉粥样硬化的证据正在不断完善,但PM2.5引发动脉粥样硬化的机制仍然有限,尤其是室内PM2.5。需要研究人员后续努力来提高对PM2.5和动脉粥样硬化的认识。预防或避免PM2.5引起的内皮损伤可能会大大减少动脉粥样硬化的发生和发展。
更新日期:2020-12-04
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