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Clinical, histopathologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma
The Journal of Veterinary Diagnostic Investigation ( IF 1.5 ) Pub Date : 2020-12-02 , DOI: 10.1177/1040638720978172
Kevin M O'Brien 1 , Braelyn J Bankoff 1 , Peri K Rosenstein 1 , Daphne C Clendaniel 2 , Melissa D Sánchez 3 , Amy C Durham 1
Affiliation  

In this retrospective descriptive study, we characterized the clinical, histologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma (GB-NEC). Immunohistochemical stains for neuroendocrine (neuron-specific enolase [NSE], chromogranin A, synaptophysin) and gastrin markers were evaluated, and clinicopathologic and follow-up data were obtained for all cases. The average age at diagnosis was 8.9 y, and breeds included 6 Boston Terriers, 2 Bichon Frise, 1 Poodle, 1 English Bulldog, 1 French Bulldog, and 2 mixed-breed dogs. Boston Terriers were overrepresented in this cohort, and therefore a breed predilection is possible. Most dogs were presented with emesis and elevated liver enzyme activities: 13 of 13 had elevated alanine aminotransferase and alkaline phosphatase activities; 8 of 13 had elevated aspartate aminotransferase activity; 7 of 13 had elevated gamma-glutamyl transferase activity. Abdominal ultrasound and/or exploratory surgery revealed a gallbladder mass. All neoplasms had similar histologic features and positive immunoreactivity for NSE, chromogranin A, synaptophysin, and gastrin. Vascular invasion was noted in 8 of 13 neoplasms, and metastasis was present in 6 of 13 cases (4 hepatic and 2 pulmonary metastases). The median survival time was 3.7 y in patients who died; 5 of 8 deaths were directly attributed to the GB-NEC, 3 of which had metastatic spread. GB-NECs have the potential to metastasize; however, surgical excision may be curative in a subset of dogs.



中文翻译:

犬胆囊神经内分泌癌13例临床、组织病理及免疫组化特征

在这项回顾性描述性研究中,我们描述了 13 例犬胆囊神经内分泌癌 (GB-NEC) 的临床、组织学和免疫组织化学特征。评估了神经内分泌(神经元特异性烯醇化酶 [NSE]、嗜铬粒蛋白 A、突触素)和胃泌素标志物的免疫组织化学染色,并获得了所有病例的临床病理学和随访数据。诊断时的平均年龄为 8.9 岁,品种包括 6 只波士顿梗犬、2 只比熊弗里斯犬、1 只贵宾犬、1 只英国斗牛犬、1 只法国斗牛犬和 2 只混种犬。波士顿梗犬在该队列中的比例过高,因此可能存在品种偏好。大多数狗出现呕吐和肝酶活性升高:13 只中有 13 只的丙氨酸转氨酶和碱性磷酸酶活性升高;13 人中有 8 人天冬氨酸转氨酶活性升高;13 人中有 7 人的 γ-谷氨酰转移酶活性升高。腹部超声和/或探查手术显示胆囊肿块。所有肿瘤具有相似的组织学特征和 NSE、嗜铬粒蛋白 A、突触素和胃泌素的阳性免疫反应性。13 例肿瘤中有 8 例出现血管侵犯,13 例中有 6 例出现转移(4 例肝转移和 2 例肺转移)。死亡患者的中位生存时间为 3.7 年;8 例死亡中有 5 例直接归因于 GB-NEC,其中 3 例发生转移性扩散。GB-NECs 有转移的潜力;然而,手术切除可能对一部分犬有治愈作用。腹部超声和/或探查手术显示胆囊肿块。所有肿瘤具有相似的组织学特征和 NSE、嗜铬粒蛋白 A、突触素和胃泌素的阳性免疫反应性。13 例肿瘤中有 8 例出现血管侵犯,13 例中有 6 例出现转移(4 例肝转移和 2 例肺转移)。死亡患者的中位生存时间为 3.7 年;8 例死亡中有 5 例直接归因于 GB-NEC,其中 3 例发生转移性扩散。GB-NECs 有转移的潜力;然而,手术切除可能对一部分犬有治愈作用。腹部超声和/或探查手术显示胆囊肿块。所有肿瘤具有相似的组织学特征和 NSE、嗜铬粒蛋白 A、突触素和胃泌素的阳性免疫反应性。13 例肿瘤中有 8 例出现血管侵犯,13 例中有 6 例出现转移(4 例肝转移和 2 例肺转移)。死亡患者的中位生存时间为 3.7 年;8 例死亡中有 5 例直接归因于 GB-NEC,其中 3 例发生转移性扩散。GB-NECs 有转移的潜力;然而,手术切除可能对一部分犬有治愈作用。13 例中有 6 例出现转移(肝转移 4 例,肺转移 2 例)。死亡患者的中位生存时间为 3.7 年;8 例死亡中有 5 例直接归因于 GB-NEC,其中 3 例发生转移性扩散。GB-NECs 有转移的潜力;然而,手术切除可能对一部分犬有治愈作用。13 例中有 6 例出现转移(肝转移 4 例,肺转移 2 例)。死亡患者的中位生存时间为 3.7 年;8 例死亡中有 5 例直接归因于 GB-NEC,其中 3 例发生转移性扩散。GB-NECs 有转移的潜力;然而,手术切除可能对一部分犬有治愈作用。

更新日期:2020-12-04
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