Here, we report the design, synthesis, and functional testing of enzyme-powered porous micromotors built from a metal-organic framework (MOF). We began by subjecting a presynthesized microporous UiO-type MOF to ozonolysis, to confer it with mesopores sufficiently large to adsorb and host the enzyme catalase (size: 6-10 nm). We then encapsulated catalase inside the mesopores, observing that they are hosted in those mesopores located at the subsurface of the MOF crystals. In the presence of H2O2 fuel, MOF motors (or MOFtors) exhibit jet-like propulsion enabled by enzymatic generation of oxygen bubbles. Moreover, thanks to their hierarchical pore system, the MOFtors retain sufficient free space for adsorption of additional targeted species, which we validated by testing a MOFtor for removal of rhodamine B during self-propulsion.

中文翻译：

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由分层微孔和介孔 UiO 型金属-有机框架构建的酶驱动多孔微电机

在这里，我们报告了由金属有机框架 (MOF) 构建的酶驱动多孔微电机的设计、合成和功能测试。我们首先对预先合成的微孔 UiO 型 MOF 进行臭氧分解，使其具有足够大的中孔以吸附和承载过氧化氢酶（大小：6-10 nm）。然后我们将过氧化氢酶封装在中孔内，观察它们位于位于 MOF 晶体亚表面的那些中孔中。在存在 H2O2 燃料的情况下，MOF 发动机（或 MOFtors）表现出通过酶促产生氧气泡实现的喷射状推进。此外，由于它们的分级孔隙系统，MOFtors 保留了足够的自由空间来吸附额外的目标物种，我们通过测试 MOFtor 在自推进过程中去除罗丹明 B 来验证这一点。