Aims: As the number of older people with dementia increases, safe pharmacotherapy in this population has attracted attention in recent years. The aims of this study were to clarify the prescribing patterns in older patients who were prescribed anti-dementia drugs and to investigate the association of potentially inappropriate medications (PIMs) with the use of anti-dementia drugs. Methods: Adults aged ≥65 years, who were prescribed anti-dementia drugs at 585 pharmacies across Japan (N = 7,953), were surveyed. The percentage of prescriptions of anti-dementia drugs and the effect of those prescriptions on PIMs were investigated. Results: Prescriptions of anti-dementia drugs were found in 4.4% of the entire study population. A multiple logistic regression analysis revealed that the use of anti-dementia drugs reduced the risk of prescribing psychotropic drugs, which represented PIMs, and that a combination of anti-dementia drugs (e.g., cholineesterase inhibitor with memantine) may reduce the risk of prescribing PIMs compared with monotherapy. Conclusion: The use of anti-dementia drugs was associated with fewer prescriptions of drugs considered as PIMs.
Dement Geriatr Cogn Disord

中文翻译：

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抗痴呆症药物的使用降低了潜在不适当药物的风险：对全国范围内处方药调查的次级分析

目的：随着老年痴呆症患者数量的增加，近年来安全的药物治疗已引起人们的关注。这项研究的目的是阐明处方抗痴呆药物的老年患者的处方模式，并调查可能不适当的药物（PIM）与抗痴呆药物的相关性。方法：调查了在日本的585家药房中使用抗痴呆药的≥65岁成年人（ N = 7953）。研究了抗痴呆药物处方的百分比以及这些处方对PIM的影响。结果：在整个研究人群中发现了4.4％的抗痴呆药处方。多元logistic回归分析显示，使用抗痴呆药可降低开具PIM代表的精神药物的风险，并且将抗痴呆药（例如，胆碱酯酶抑制剂与美金刚）联用可降低开具PIM的风险与单一疗法相比。结论：抗痴呆药物的使用与被视为PIM的药物处方较少有关。
Dement Geriatr Cogn Disord