The two-minute walk test (2MWT) is a frequently used walking capacity test in persons with multiple sclerosis (pwMS). However, less is known about its relevance with regards to walking capacity during free-living walking performance. Therefore, the ecological validity of the 2MWT was tested by 1. computing free-living minutes with the same intensity (cadence) as during the 2MWT and 2. investigating the relationship between 2MWT cadence and minutes with the same cadence during free-living walking. 20 pwMS aged 44.2 ± 12.2 (Expanded Disability Status Scale (EDSS) score of 3.1 ± 1.4) performed a 2MWT and wore an accelerometer for seven days. The number of pwMS reaching 100%, 90%, 80% or 70% of 2MWT cadence for at least one minute a day and minutes/day with at least 100%, 90%, 80% and 70% of 2MWT cadence during free-living walking was calculated. Six participants reached 100% of the 2MWT cadence for at least one minute/day during free-living walking. A total of 80% 2MWT cadence was the first intensity category that was reached by all participants during free-living walking. No significant correlation was found between cadence in the 2MWT and minutes in which this cadence was reached during free-living walking. Ecological validity with regard to walking intensity could not be confirmed in our study sample.

中文翻译：

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多发性硬化症患者的两分钟步行测试：踏频与自由活动步行的相关性不支持生态有效性

两分钟步行测试（2MWT）是多发性硬化症（pwMS）患者的常用步行能力测试。但是，人们对自由活动步行过程中步行能力的相关性了解甚少。因此，通过以下方法测试了2MWT的生态有效性：1.计算与2MWT相同强度（节奏）的自由活动分钟数； 2.研究2MWT节奏与自由行走过程中相同节奏的分钟数之间的关系。20 pwMS年龄为44.2±12.2（扩展的残疾状态量表（EDSS）评分为3.1±1.4），进行了2MWT的测试，并佩戴了加速度计七天。每天至少一分钟和每天每天至少一分钟达到2MWT节奏的100％，90％，80％或70％的pwMS数量，在自由操作期间至少达到2MWT节奏的100％，90％，80％和70％计算了生活步行。自由活动期间，每天有至少六分钟的参与者达到1％的2MWT节奏。共有80％的2MWT节奏是所有参与者在自由生活步行中达到的第一个强度类别。在2MWT的踏频与自由行走期间达到该踏频的分钟之间未发现显着相关性。在我们的研究样本中，无法确定关于步行强度的生态有效性。