There is an association between the consumption of artificial sweeteners and Type 2 diabetes in cohort studies, but intervention studies do not show a clear elevation of blood glucose after the use of artificial sweeteners. The objective of this study was to examine whether two commonly used artificial sweeteners had an adverse effect on glucose control in normal-weight subjects, and in overweight and obese subjects when consumed for 2 weeks. In the study, 39 healthy subjects (body-mass index, kg/m²) (18–45) without Type 2 diabetes with an age of 18–75 years were randomly assigned to 0.6 L/day of an artificially sweetened soft drink containing acesulfame K (950) and aspartame (951) or 0.6 L/day of mineral water for 2 weeks each in a crossover study. There was a 4 week washout period with no drinks consumed. Glucose levels were read by a continuous glucose monitor (CGM) during each 2 week period. A 75 g oral glucose-tolerance test (OGTT) was performed at the beginning and end of each intervention period. Blood samples were collected at baseline, and 1 and 2 h for glucose and insulin. A 2 week intake of artificially sweetened beverage (ASB) did not alter concentrations of fasting glucose and fasting insulin, the area under the curve (AUC) for OGTT glucose and insulin, the incremental area under the curve (iAUC) for OGTT glucose and insulin, the homeostatic model assessment for insulin resistance (HOMA-IR), and the Matsuda index compared with the baseline and with the changes after a 2 week intake of mineral water. Continuous 2 week glucose concentrations were not significantly different after a 2 week intake of ASB compared with a 2 week intake of mineral water. This study found no harmful effect of the artificially sweetened soft drink containing acesulfame K (950) and aspartame (951) on glucose control when consumed for 2 weeks by people without Type 2 diabetes.

中文翻译：

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含阿斯巴甜和乙酰磺胺酸钾的饮料两周的食用量并没有不利地影响成年男性和女性的葡萄糖代谢：一项随机交叉研究

在队列研究中，食用人造甜味剂与2型糖尿病之间存在关联，但是干预研究并未显示使用人造甜味剂后血糖明显升高。这项研究的目的是检查两种常用的人造甜味剂是否对正常体重的受试者以及超重和肥胖的受试者食用2周后的血糖控制有不利影响。在这项研究中，有39名健康受试者（体重指数，kg / m ²）（18-45岁），年龄在18-75岁之间且没有2型糖尿病的人被随机分配为每天0.6升的人工甜味软饮料，其中包含乙酰磺胺酸钾（950）和阿斯巴甜（951）或每天0.6升的矿物质在交叉研究中各浇水2周。有一个为期4周的冲洗期，没有喝酒。在每个2周的时间内，通过连续血糖监测仪（CGM）读取葡萄糖水平。在每个干预期的开始和结束时进行75 g口服葡萄糖耐量试验（OGTT）。在基线时以及分别在1和2小时时采集血糖和胰岛素的血液样本。摄入人造甜味饮料（ASB）2周不会改变空腹血糖和空腹胰岛素的浓度，OGTT葡萄糖和胰岛素的曲线下面积（AUC），OGTT葡萄糖和胰岛素的曲线下面积（iAUC） ，胰岛素抵抗的稳态模型评估（HOMA-IR），以及Matsuda指数与基线以及摄入矿泉水2周后的变化的比较。摄入2周的ASB与摄入2周的矿泉水相比，连续2周的葡萄糖浓度无显着差异。这项研究发现，当非2型糖尿病患者食用2周时，含有乙酰磺胺酸钾（950）和阿斯巴甜（951）的人工甜味软饮料对血糖控制没有有害影响。