Hippo signaling pathway is a highly conserved and familiar tissue growth regulator, primarily dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein (YAP) is the key transcriptional effector molecule, which is under negative regulation of the Hippo pathway. Wealth of studies have identified crucial roles of Hippo/YAP signaling pathway during the process of development, including the development of neuronal system. We provide here, an overview of the contributions of this signaling pathway at multiple stages of neuronal development including, proliferation of neural stem cells (NSCs), migration of NSCs toward their destined niche, maintaining NSCs in the quiescent state, differentiation of NSCs into neurons, neuritogenesis, synaptogenesis, brain development, and in neuronal apoptosis. Hyperactivation of the neuronal Hippo pathway can also lead to a variety of devastating neurodegenerative diseases. Instances of aberrant Hippo pathway leading to neurodegenerative diseases along with the approaches utilizing this pathway as molecular targets for therapeutics has been highlighted in this review. Recent evidences suggesting neuronal repair and regenerative potential of this pathway has also been pointed out, that will shed light on a novel aspect of Hippo pathway in regenerative medicine. Our review provides a better understanding of the significance of Hippo pathway in the journey of neuronal system from development to diseases as a whole.

中文翻译：

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神经元河马信号：从发育到疾病

Hippo信号通路是一种高度保守和熟悉的组织生长调节剂，主要处理细胞存活、细胞增殖和凋亡。Yes 相关蛋白 (YAP) 是关键的转录效应分子，受 Hippo 通路的负调控。大量研究已经确定了 Hippo/YAP 信号通路在发育过程中的关键作用，包括神经元系统的发育。我们在这里概述了该信号通路在神经元发育的多个阶段的贡献，包括神经干细胞 (NSCs) 的增殖、NSCs 向其注定的生态位迁移、将 NSCs 维持在静止状态、NSCs 分化为神经元、神经发生、突触发生、大脑发育和神经元凋亡。神经元 Hippo 通路的过度激活也可导致多种破坏性神经退行性疾病。本综述重点介绍了导致神经退行性疾病的异常 Hippo 通路的实例以及利用该通路作为分子靶点进行治疗的方法。最近的证据表明该途径的神经元修复和再生潜力也被指出，这将阐明再生医学中 Hippo 途径的一个新方面。我们的综述提供了对 Hippo 通路在神经元系统从发育到整个疾病过程中的重要性的更好理解。本综述重点介绍了导致神经退行性疾病的异常 Hippo 通路的实例以及利用该通路作为分子靶点进行治疗的方法。最近的证据表明该途径的神经元修复和再生潜力也被指出，这将阐明再生医学中 Hippo 途径的一个新方面。我们的综述提供了对 Hippo 通路在神经元系统从发育到整个疾病过程中的重要性的更好理解。本综述重点介绍了导致神经退行性疾病的异常 Hippo 通路的实例以及利用该通路作为分子靶点进行治疗的方法。最近的证据表明该途径的神经元修复和再生潜力也被指出，这将阐明再生医学中 Hippo 途径的一个新方面。我们的综述提供了对 Hippo 通路在神经元系统从发育到整个疾病过程中的重要性的更好理解。