Cyclization of ynone‐oximes with a gold catalyst to obtain new 4H‐1,2‐oxazines was reported. During cyclization, alcohol derivatives are specifically and selectively added to the ring. Under the same reaction conditions, amine or thiol derivatives do not give a nucleophilic addition reaction. Alcohol derivatives such as cholesterol, phenol or iso‐propanol were quickly added to the cyclic product. The proposed reaction mechanism was supported by performing control experiments, and DFT studies. More information can be found in the Communication by Volkan Taşdemir and Nurettin Menges.

中文翻译：

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封面人物：非共轭亚胺肟衍生物的金催化环化：溶剂分子的掺入（Asian J. Org。Chem。12/2020）

据报道，用金催化剂将炔酮肟环化以获得新的4H-1，2-恶嗪。在环化过程中，将醇衍生物特异性和选择性地加到环上。在相同的反应条件下，胺或硫醇衍生物不会产生亲核加成反应。诸如胆固醇，苯酚或异丙醇之类的醇衍生物被快速添加到环状产物中。拟议的反应机理得到了进行对照实验和DFT研究的支持。可以在VolkanTaşdemir和Nurettin Menges的来文中找到更多信息。