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miRNA biomarkers for predicting overall survival outcomes for head and neck squamous cell carcinoma
Genomics ( IF 4.4 ) Pub Date : 2020-12-03 , DOI: 10.1016/j.ygeno.2020.12.002
Zeng-Hong Wu 1 , Yi Zhong 2 , Tao Zhou 2 , Hong-Jun Xiao 2
Affiliation  

Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor of the upper aerodigestive tract. The loss and gain of miRNA function promote cancer development through various mechanisms. RNA sequencing (RNA-seq) and miRNAs sequencing data from the Cancer Genome Atlas (TCGA) was used to show the dysfunctional miRNAs microenvironment and to provide useful biomarkers for miRNAs therapy. Seven miRNAs were found to be independent prognostic factors of HNSCC patients in the training cohort. A total of 60 target genes for these miRNAs were predicted. Nine target genes (CDCA4, CXCL14, FLNC, KLF7, NBEAL2, P4HA1, PFKM, PFN2 and SEPPINE1) were correlated with patient's overall survival (OS) outcomes. We identified novel miRNAs markers for the prognosis of head and neck squamous cell carcinoma.



中文翻译:

用于预测头颈部鳞状细胞癌总体生存结果的 miRNA 生物标志物

头颈部鳞状细胞癌(HNSCC)是上呼吸消化道的恶性肿瘤。miRNA功能的丧失和获得通过各种机制促进癌症的发展。来自癌症基因组图谱 (TCGA) 的 RNA 测序 (RNA-seq) 和 miRNAs 测序数据用于显示功能失调的 miRNAs 微环境,并为 miRNAs 治疗提供有用的生物标志物。在训练队列中发现七种 miRNA 是 HNSCC 患者的独立预后因素。预测了这些 miRNA 的总共 60 个靶基因。九个靶基因(CDCA4CXCL14FLNCKLF7NBEAL2P4HA1PFKMPFN2SEPPINE1 ) 与患者的总生存期 (OS) 结果相关。我们确定了用于头颈部鳞状细胞癌预后的新型 miRNA 标志物。

更新日期:2020-12-10
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