当前位置: X-MOL 学术Mediat. Inflamm. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Free Fatty Acids and Their Inflammatory Derivatives Affect BDNF in Stroke Patients
Mediators of Inflammation ( IF 4.6 ) Pub Date : 2020-12-03 , DOI: 10.1155/2020/6676247
Dariusz Kotlega 1, 2 , Agnieszka Zembron-Lacny 2 , Barbara Morawin 2 , Monika Golab-Janowska 1 , Przemyslaw Nowacki 1 , Malgorzata Szczuko 3
Affiliation  

Objective. The neurotrophin brain-derived neurotrophic factor (BDNF) affects poststroke functional outcome, neurogenesis, neuroprotection, and neuroplasticity. Its level is related to the diet and nutritional status, and more specifically, it is free fatty acids (FFAs) and eicosanoids that can have an impact on the BDNF level. The aim of this study was to analyze the potential impact of FFAs and eicosanoids on the BDNF level in stroke patients. Material and Methods. Seventy-three ischemic stroke patients were prospectively enrolled in the study. Laboratory tests were performed in all subjects, including the levels of FFAs, eicosanoids, and BDNF. FFAs and inflammatory metabolites were determined by gas chromatography and liquid chromatography, while BDNF was evaluated by the immune-enzymatic method (ELISA). Results. The plasma level of BDNF negatively correlated with C22:1n9 13 erucic acid, C18:3n3 linolenic acid (ALA), and lipoxin A4 15-epi-LxA4. A direct association was observed in relation to BDNF and C16:1 palmitoleic acid and C20:3n6 eicosatrienoic acid (dihomo-gamma-linolenic acid (DGLA)). Conclusions. Saturated fatty acids and omega-3 and omega-9 erucic acids can affect signaling in the BDNF synthesis resulting in the decrease in BDNF. There is a beneficial effect of DGLA on the BDNF level, while the effect of ALA on BDNF can be inhibitory. Specialized proresolving lipid mediators can play a role in the BDNF metabolism. BDNF can interact with inflammation as the risk factor in the cardiovascular disorders, including stroke.

中文翻译:

游离脂肪酸及其炎症衍生物影响中风患者的 BDNF

客观。神经营养因子脑源性神经营养因子 (BDNF) 影响中风后功能结果、神经发生、神经保护和神经可塑性。它的水平与饮食和营养状况有关,更具体地说,是游离脂肪酸 (FFA) 和类花生酸对 BDNF 水平产生影响。本研究的目的是分析 FFA 和类花生酸对中风患者 BDNF 水平的潜在影响。材料与方法. 73 名缺血性卒中患者被前瞻性纳入研究。对所有受试者进行了实验室测试,包括 FFA、类花生酸和 BDNF 的水平。FFAs和炎症代谢物通过气相色谱和液相色谱测定,而BDNF通过免疫酶法(ELISA)评估。结果。BDNF 的血浆水平与 C22:1n9 13 芥酸、C18:3n3 亚麻酸 (ALA) 和脂氧素 A4 15-epi-LxA4 呈负相关。观察到与 BDNF 和 C16:1 棕榈油酸和 C20:3n6 二十碳三烯酸(二高-γ-亚麻酸 (DGLA))相关的直接关联。结论. 饱和脂肪酸和 omega-3 和 omega-9 芥酸可以影响 BDNF 合成中的信号传导,导致 BDNF 减少。DGLA 对 BDNF 水平有有益作用,而 ALA 对 BDNF 的作用可能是抑制性的。专门的促分解脂质介质可以在 BDNF 代谢中发挥作用。BDNF 可以与炎症相互作用,作为心血管疾病(包括中风)的危险因素。
更新日期:2020-12-03
down
wechat
bug