Non-invasive prenatal testing (NIPT) is used worldwide to screen for fetal aneuploidy. Although previous studies on the psychosocial aspects of NIPT have focused on satisfaction regarding the test, we surveyed women who experienced negative emotions after receiving NIPT. From January 2018 to March 2019, we surveyed pregnant women whose NIPT results were negative, one year after the test. Of the 526 respondents, 35 (6.7%) regretted receiving NIPT and blamed themselves for taking it. We assigned this 6.7% of respondents to the negative emotion group. Although, 76.5% of the participants in the negative emotion group reported they would like to take NIPT for their next pregnancy, it was significantly lower as compared to the control group (92%). Furthermore, 31.9% of respondents in the control group reported that they would recommend similar tests to their relatives and friends. Conversely, in the negative emotion group, this proportion was lower at 17.1%. This suggests that guilt over testing may be meaningful. Thus, this study showed that some NIPT examinees regretted taking the test and blamed themselves. Respondents reported experiencing stress, anxiety, and depression even before NIPT affirming that it is important to address pregnant women’s psychosocial status during pre-test genetic counseling.

无创产前检测 (NIPT) 在世界范围内用于筛查胎儿非整倍体。尽管之前关于 NIPT 的社会心理方面的研究侧重于对测试的满意度，但我们对接受 NIPT 后经历负面情绪的女性进行了调查。2018 年 1 月至 2019 年 3 月，我们对 NIPT 结果为阴性的孕妇进行了调查，时间为一年后。在 526 名受访者中，35 人 (6.7%) 后悔接受 NIPT 并责怪自己接受了它。我们将这 6.7% 的受访者分配到负面情绪组。虽然，76.5% 的负面情绪组参与者表示他们希望在下次怀孕时接受 NIPT，但与对照组 (92%) 相比，这一比例显着降低。此外，31。对照组中 9% 的受访者表示，他们会向亲友推荐类似的测试。相反，在负面情绪组中，这一比例较低，为 17.1%。这表明对测试的内疚可能是有意义的。因此，这项研究表明，一些 NIPT 考生后悔参加考试并自责。受访者报告甚至在 NIPT 之前就经历了压力、焦虑和抑郁，确认在测试前遗传咨询期间解决孕妇的社会心理状况很重要。