A high incidence of heterotopic ossification (HO) has been reported in patients with diffuse idiopathic skeletal hyperostosis (DISH), a metabolic disease characterized by calcifications of entheses at spine and peripheral sites. We performed histological and immunohistochemical analyses in five different HO sites in a patient with DISH to study a possible mutual interaction of bone morphogenetic protein 2 (BMP-2), transforming growth factor beta (TGF-β), and decorin, crucial for bone mass increasing, matrix calcification, and endochondral bone formation. We speculated that the surgical trauma triggered HO, inducing TGF-β release at the lesion site. TGF-β recruits osteoblast precursor cells and determines the overexpression of BMP-2 in the surrounding skeletal muscle, inducing a further osteogenic differentiation, contributing to HO onset.

弥漫性特发性骨骼肥大症（DISH）患者的异位骨化症（HO）发生率很高，这是一种以脊柱和周围部位的钙化为特征的代谢性疾病。我们在DISH患者的五个不同的HO部位进行了组织学和免疫组化分析，以研究骨形态发生蛋白2（BMP-2），转化生长因子β（TGF-β）和decorin对骨量至关重要的可能的相互作用增加，基质钙化和软骨内骨形成。我们推测手术创伤触发了HO，诱导了病变部位的TGF-β释放。TGF-β募集成骨细胞前体细胞，并确定周围骨骼肌中BMP-2的过度表达，诱导进一步的成骨分化，从而促进HO的发作。