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Study of haemolysis interference limit on serum potassium assay on Roche® Cobas 8000 and evaluation of corrected potassium
Scandinavian Journal of Clinical and Laboratory Investigation ( IF 2.1 ) Pub Date : 2020-12-03 , DOI: 10.1080/00365513.2020.1855363
Claudio Ilardo 1 , Amandine Lancien 1 , Joël Barthes 1
Affiliation  

Abstract

Roche Diagnostics® decided a more restrictive haemolysis index (≤20 HI) for approval the release of serum potassium results. This study examined the risk of overestimating serum potassium results related to the HI according to the Ricos total error (±5.6%) and evaluated the approach of Martinez-Morillo and Alvarez to determine a corrected potassium. According to Ricos’ criteria, our study showed compliant potassium results with HI less than or equal to 75. Between 90 and 100 HI, the results did not show a significant overestimation. The equation to obtain Kcorrected was: Kmeasured – (0.004 × HI). The use of corrective formulas for adjusting results of potassium could help the laboratory to identify patients at increased risk and to repeat the test as soon as possible.



中文翻译:

罗氏 Cobas 8000 血清钾测定溶血干扰限度的研究及校正钾的评价

摘要

Roche Diagnostics ®决定采用更严格的溶血指数 (≤20 HI) 来批准血清钾结果的发布。本研究根据 Ricos 总误差 (±5.6%) 检查了高估与 HI 相关的血清钾结果的风险,并评估了 Martinez-Morillo 和 Alvarez 确定校正钾的方法。根据 Ricos 的标准,我们的研究显示符合 HI 小于或等于 75 的钾结果。在 90 和 100 HI 之间,结果没有显示出明显的高估。获得 K修正的方程是: K测量– (0.004 × HI)。使用校正公式来调整钾的结果可以帮助实验室识别风险增加的患者并尽快重复测试。

更新日期:2021-02-09
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