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3D-printed porous tantalum: recent application in various drug delivery systems to repair hard tissue defects
Expert Opinion on Drug Delivery ( IF 6.6 ) Pub Date : 2021-01-19 , DOI: 10.1080/17425247.2021.1860015
Long Hua 1, 2 , Ting Lei 1 , Hu Qian 1 , Yu Zhang 1 , Yihe Hu 1 , Pengfei Lei 1, 3
Affiliation  

ABSTRACT

Introduction

The treatment of hard tissue defects, especially those of bone and cartilage, induced by infections or tumors remains challenging. Traditional methods, including debridement with systematic chemotherapy, have shortcomings owing to their inability to eliminate infections and high systematic toxicity.

Area covered

This review comprehensively summarizes and discusses the current applications of 3D-printed porous tantalum (3D-P-p-Ta), a novel drug delivery strategy, in drug delivery systems to repair hard tissue defects, as well as the limitations of existing data and potential future research directions.

Expert opinion

Drug delivery systems have advanced medical treatments, with the advantages of high local drug concentration, long drug-release period, and minimal systematic toxicity. Due to its excellent biocompatibility, ideal mechanical property, and anti-corrosion ability, porous tantalum is one of the most preferable loading scaffolds. 3D printing allows for freedom of design and facilitates the production of regular porous implants with high repeatability. There are several reports on the application of 3D-P-p-Ta in drug delivery systems for the management of infection- or tumor-associated bone defects, yet, to the best of our knowledge, no reviews have summarized the current research progress.



中文翻译:

3D 打印多孔钽:最近在各种药物输送系统中的应用,以修复硬组织缺陷

摘要

介绍

由感染或肿瘤引起的硬组织缺损,尤其是骨和软骨缺损的治疗仍然具有挑战性。传统方法,包括系统化疗清创术,由于无法消除感染和高系统毒性而存在缺陷。

覆盖面积

本综述全面总结和讨论了 3D 打印多孔钽 (3D-Pp-Ta) 这种新型药物递送策略在修复硬组织缺陷的药物递送系统中的当前应用,以及现有数据的局限性和潜在的未来研究方向。

专家意见

给药系统具有先进的医学治疗方法,具有局部药物浓度高、药物释放时间长、全身毒性最小等优点。由于其优异的生物相容性、理想的机械性能和抗腐蚀性能,多孔钽是最优选的负载支架之一。3D 打印允许设计自由并促进具有高重复性的常规多孔植入物的生产。有几份关于 3D-Pp-Ta 在药物递送系统中应用以管理感染或肿瘤相关骨缺损的报告,但据我们所知,没有综述总结当前的研究进展。

更新日期:2021-01-19
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