G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled heterotrimeric G proteins can dramatically alter the signalling landscape and functional state of a cell. Consistent with their fundamental physiological functions, GPCRs and their effector heterotrimeric G proteins are implicated in some of the most prevalent human diseases, including a complex disease such as cancer that causes significant morbidity and mortality worldwide. GPCR/G protein‐mediated signalling impacts oncogenesis at multiple levels by regulating tumour angiogenesis, immune evasion, metastasis, and drug resistance. Here, we summarize the growing body of research on GPCRs and their effector heterotrimeric G proteins as drivers of cancer initiation and progression, and as emerging antitumoural therapeutic targets.

中文翻译：

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G 蛋白偶联受体和异三聚体 G 蛋白作为癌症驱动因子

G 蛋白偶联受体 (GPCR) 和异源三聚体 G 蛋白在多种细胞过程中发挥核心作用。因此，GPCRs 及其偶联的异源三聚体 G 蛋白的失调可以显着改变细胞的信号景观和功能状态。与它们的基本生理功能一致，GPCR 及其效应异源三聚体 G 蛋白与一些最普遍的人类疾病有关，包括一种复杂的疾病，如在全球范围内导致显着发病率和死亡率的癌症。GPCR/G 蛋白介导的信号通过调节肿瘤血管生成、免疫逃避、转移和耐药性在多个层面影响肿瘤发生。这里，