The infusion of Chrysophyllum albidum was investigated for its antidiabetic mechanism by studying its ability to promote glucose uptake and utilization as well as its modulatory effect on metabolic activities linked to type 2 diabetes in isolated psoas muscle. Isolated psoas muscle was incubated with different concentrations of the infusion in the presence of glucose at 37°C for 2 hr. The infusion improved muscle glucose uptake, with concomitant elevated muscular levels of glutathione, superoxide dismutase, catalase, and ectonucleotidase activities, while depleting malondialdehyde, nitric oxide, adenosine triphosphatase, acetylcholinesterase, glycogen phosphorylase, glucose 6‐phosphatase, fructose‐1,6‐biphosphatase, and lipase activities. It also maintained muscular morphology, while increasing magnesium, calcium, and iron levels. The infusion inhibited α‐glucosidase and α‐amylase activities in vitro. LC‐MS analysis of the infusion revealed the presence of phenolics. These results indicate that C. albidum may mediate antidiabetic activities by stimulating muscle glucose uptake and modulation of key metabolisms linked to diabetes.

中文翻译：

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非洲星苹果 (Chrysophyllum albidum G. Don) 的生物活性化合物及其对离体大鼠腰大肌 2 型糖尿病相关代谢活动的调节作用

白菊花输液通过研究其促进葡萄糖摄取和利用的能力以及其对孤立腰大肌中与 2 型糖尿病相关的代谢活动的调节作用，研究了其抗糖尿病机制。将分离的腰大肌与不同浓度的输液在葡萄糖存在下于 37°C 孵育 2 小时。输液改善了肌肉对葡萄糖的摄取，同时提高了肌肉的谷胱甘肽、超氧化物歧化酶、过氧化氢酶和外核苷酸酶活性，同时消耗了丙二醛、一氧化氮、三磷酸腺苷酶、乙酰胆碱酯酶、糖原磷酸化酶、葡萄糖 6-磷酸酶、果糖-1,6-双磷酸酶和脂肪酶活性。它还保持了肌肉形态，同时增加了镁、钙和铁的水平。输液在体外抑制α-葡萄糖苷酶和α-淀粉酶活性。输液的 LC-MS 分析显示存在酚类物质。这些结果表明C. albidum可通过刺激肌肉葡萄糖摄取和调节与糖尿病相关的关键代谢来介导抗糖尿病活动。