Enantioselective, Stereoconvergent Resolution Copolymerization of Racemic cis‐Internal Epoxides and Anhydrides,Angewandte Chemie International Edition

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Enantioselective, Stereoconvergent Resolution Copolymerization of Racemic cis‐Internal Epoxides and Anhydrides
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2020-12-03 , DOI: 10.1002/anie.202011259
Guang‐Hui He ₁ , Bai‐Hao Ren ₁ , Shi‐Yu Chen ₁ , Ye Liu ₁ , Xiao‐Bing Lu ₁

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Unprecedented enantioselective resolution copolymerization of racemic cis‐internal epoxides and anhydrides was mediated by dinuclear aluminum complexes with multiple chirality, affording optically active polyesters with two contiguous stereogenic centers, and the unreacted substrates in good enantioselectivity. Unexpected stereoconvergence is observed in this resolution copolymerization, where the selectivity factor for the enantioselective formation of copolymer significantly exceeds the kinetic resolution coefficient based on the unreacted epoxide at various conversions. Catalytic activity and copolymer enantioselectivity are strongly influenced by the phenolate ortho‐substituents of the ligand set, as well as the axial linker and its chirality. An enantiopure binaphthol‐linked bimetallic Al^III complex allows stereoconvergent access to the stereoregular semi‐crystalline polyesters and a concomitant kinetic resolution of the epoxide substrates.

更新日期：2020-12-03

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