Magnetoencephalography (MEG) measures magnetic fields generated by synchronised neural current flow and provides direct inference on brain electrophysiology and connectivity, with high spatial and temporal resolution. The movement-related beta decrease (MRBD) and the post-movement beta rebound (PMBR) are well-characterised effects in magnetoencephalography (MEG), with the latter having been shown to relate to long-range network integrity. Our previous work has shown that the PMBR is diminished (relative to controls) in a group of schizophrenia patients. However, little is known about how this effect might differ in patients at different stages of illness and degrees of clinical severity. Here, we extend our previous findings showing that the MEG derived PMBR abnormality in schizophrenia exists in 29 recent-onset and 35 established cases (i.e., chronic patients), compared to 42 control cases. In established cases, PMBR is negatively correlated with severity of disorganization symptoms. Further, using a hidden Markov model analysis, we show that transient pan-spectral oscillatory ”bursts”, which underlie the PMBR, differ between healthy controls and patients. Results corroborate that PMBR is associated with disorganization of mental activity in schizophrenia.

脑磁图 (MEG) 测量同步神经电流产生的磁场，并以高空间和时间分辨率提供对大脑电生理学和连接性的直接推断。运动相关的 β 减少 (MRBD) 和运动后 β 反弹 (PMBR) 是脑磁图 (MEG) 中典型的效应，后者已被证明与远程网络完整性相关。我们之前的工作表明，在一组精神分裂症患者中，PMBR 有所减弱（相对于对照组）。然而，人们对这种效应在不同疾病阶段和临床严重程度的患者中可能有何不同知之甚少。在这里，我们扩展了之前的研究结果，表明精神分裂症中的 MEG 衍生的 PMBR 异常存在于 29 名新近发病的病例和 35 名既定病例（即慢性患者）中，相比之下，42 名对照病例存在这种异常。在既定病例中，PMBR 与紊乱症状的严重程度呈负相关。此外，使用隐马尔可夫模型分析，我们表明，作为 PMBR 基础的瞬态全谱振荡“爆发”在健康对照和患者之间存在差异。结果证实 PMBR 与精神分裂症患者的精神活动紊乱有关。