Levoglucosenone reacted with α-ethoxycarbonyl- and α-nitrocyclododecanones, leading to the formation of diastereomeric Michael adducts in high yields. Methods were developed for the denitration of the respective nitroadducts by treatment with Raney nickel and Bu3SnH, allowing to optimize the synthesis of a 16-membered chiral macrolide.

中文翻译：

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左旋葡糖酮与α-乙氧羰基和α-硝基环十二烷酮的迈克尔加合物：转化为手性大环内酯类

左葡糖酮与α-乙氧基羰基-和α-硝基环十二烷反应，导致高产率形成非对映体迈克尔加合物。通过用阮内镍和Bu3SnH处理，开发了相应的硝基加合物脱硝的方法，从而优化了16元手性大环内酯的合成。