The successful synthesis of novel tetrahydropyrimido[4,5-b][1,6]naphthyridine derivatives is reported. 1-Benzyl-3,5-bis[(E)-arylmethylidene] tetrahydropyridin-4(1H)-ones prepared via Knoevenagel condensation of 1-benzyl-4-piperidinone with aromatic aldehydes undergo condensation with 6-aminouracils in acetic acid to afford the desired products. Structures of the products are confirmed by analytical data and X-ray crystallography analysis.

中文翻译：

---

通过1-苄基-3,5-双[（E）-芳亚甲叉基]四氢吡啶-4-4（1 H）-与6-氨基尿嘧啶缩合反应合成新型四氢嘧啶基[4,5- B] [1,6]萘啶

据报道成功合成了新的四氢嘧啶基[4,5- b ] [1,6]萘啶衍生物。通过1-苄基-4-哌啶酮与芳香醛的Knoevenagel缩合制得的1-苄基-3,5-双[（E）-芳基亚甲基]四氢吡啶-4-4（1 H）-在乙酸中与6-氨基尿嘧啶缩合生成提供所需的产品。通过分析数据和X射线晶体学分析确认产物的结构。