Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some promising therapy targets. However, further mechanisms remain to be researched to improve the therapeutic strategy and diagnosis of HCC. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which plays critical roles in networks of different cellular processes, and TGF-β signaling has been found to participate in tumor initiation and development of HCC in recent years. Moreover, among the molecules and signaling pathways, researchers paid more attention to lncRNAs (long non-coding RNAs), but the connection between lncRNAs and TGF-βremain poorly understood. In this review, we conclude the malignant procedure which lncRNAs and TGF-β involved in, and summarize the mechanisms of lncRNAs and TGF-βin HCC initiation and development. Furthermore, the interaction between lncRNA and TGF-β are paid more attention, and the potential therapy targets are mentioned.

中文翻译：

---

长期非编码RNA对肝细胞癌TGF-β信号通路的调节

肝细胞癌（HCC）是一种预后较差的肝癌。已经证明在HCC肿瘤发生中存在许多可能的机制，并且最近的研究提供了一些有希望的治疗靶标。但是，尚需进一步研究机制以改善HCC的治疗策略和诊断。转化生长因子-β（TGF-β）是一种多效性细胞因子，在不同细胞过程的网络中起着关键作用，近年来发现TGF-β信号传导参与了HCC的肿瘤发生和发展。此外，在分子和信号通路中，研究人员更加关注lncRNA（长非编码RNA），但对lncRNA和TGF-β之间的联系仍然知之甚少。在这篇评论中 我们总结了lncRNA和TGF-β参与的恶性过程，总结了lncRNA和TGF-β在肝癌发生发展中的作用机制。此外，lncRNA与TGF-β之间的相互作用受到更多关注，并提及了潜在的治疗靶标。