Infections caused by multidrug-resistant (MDR) bacteria present an emerging global health crisis, and the threat is intensified by the involvement of biofilms. Some biofilm infections involve more than one species; this can further challenge treatment using traditional antibiotics. Nanomaterials are being developed as alternative therapeutics to traditional antibiotics; here we report biodegradable polymer-stabilized oil-in-water nanosponges (BNS) and show their activity against dual-species bacterial biofilms. The described engineered nanosponges demonstrated broad-spectrum antimicrobial activity through prevention of dual-species biofilm formation as well as eradication of preformed biofilms. The BNS showed no toxicity against mammalian cells. Together, these data highlight the therapeutic potential of this platform.

中文翻译：

---

可生物降解聚合物纳米海绵对双菌种细菌生物膜的活性

由耐多药 (MDR) 细菌引起的感染是一场新出现的全球健康危机，而生物膜的参与加剧了威胁。一些生物膜感染涉及多个物种；这可能会进一步挑战使用传统抗生素的治疗。正在开发纳米材料作为传统抗生素的替代疗法；在这里，我们报告了可生物降解的聚合物稳定的水包油纳米海绵 (BNS)，并展示了它们对双物种细菌生物膜的活性。所描述的工程纳米海绵通过防止双物种生物膜的形成以及根除预先形成的生物膜表现出广谱抗菌活性。BNS 对哺乳动物细胞没有毒性。总之，这些数据突出了该平台的治疗潜力。