当前位置: X-MOL 学术Integr. Zool. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Multidrug-resistant Proteus mirabilis isolates carrying blaOXA-1 and blaNDM-1 from wildlife in China: increasing public health risk
Integrative Zoology ( IF 3.3 ) Pub Date : 2020-12-02 , DOI: 10.1111/1749-4877.12510
Qian Kang 1 , Xue Wang 1, 2 , Jianan Zhao 1 , Zhihui Liu 1, 2 , Fang Ji 1 , Han Chang 3 , Jianchun Yang 1 , Shijia Hu 1 , Ting Jia 4 , Xiaojia Wang 5 , Jiagui Tang 5 , Guoying Dong 6 , Guocheng Hu 7 , Jing Wang 8 , Yanyu Zhang 9 , Jianhua Qin 2 , Chengmin Wang 1
Affiliation  

The emergence of multidrug resistance (MDR) in Proteus mirabilis clinical isolates is a growing public health concern and has serious implications for wildlife. What is the role of wildlife has been become one of the hot issues in disseminating antimicrobial resistance. Here, 54 P. mirabilis isolates from 12 different species were identified. Among them, 25 isolates were determined to be MDR by profile of antimicrobial susceptibility; 10 MDR P. mirabilis isolates were subjected to comparative genomic analysis by whole genome sequencing. Comprehensive analysis showed that chromosome of P. mirabilis isolates mainly carries multidrug-resistance complex elements harboring resistance to carbapenem genes blaOXA-1, blaNDM-1, and blaTEM-1. Class I integron is the insertion hotspot of IS26; it can be inserted into type I integron at different sites, thus forming a variety of multiple drug resistance decision sites. At the same time, Tn21, Tn7, and SXT/R391 mobile elements cause widespread spread of these drug resistance genes. In conclusion, P. mirabilis isolates from wildlife showed higher resistance to commonly used clinic drugs comparing to those from human. Therefore, wild animals carrying MDR clinical isolates should be paid attention to by the public health.
更新日期:2020-12-02
down
wechat
bug