Two different anhydrides having norbornene and dibenzobarrelene skeletons were synthesized from Diels‐Alder cycloaddition reactions using dienes such as anthracene and cyclopentadiene, and dienophiles like maleic acid and maleic anhydride. New benzimidazole derivatives bearing carboxamide, guanidine, and cyclic imide functional groups were obtained from these anhydrides. The compounds were investigated for their effects on MDA‐MB‐231 (Human breast cancer), A549 (Lung cancer), Ovcar3 (Human Ovarian cancer), and Panc1 (human pancreas cancer) cell lines using the MTT assay test. Compounds 4–8 demonstrated critical cytotoxic action against all cell lines.

中文翻译：

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降冰片烯/二苯并barrelene骨架和不同的官能团的苯并咪唑衍生物的合成和抗癌评价

两种不同的具有降冰片烯和二苯并戊烯骨架的酸酐是由Diels-Alder环加成反应合成的，使用二烯如蒽和环戊二烯，以及二烯亲如马来酸和马来酸酐。从这些酸酐获得了带有羧酰胺，胍和环状酰亚胺官能团的新的苯并咪唑衍生物。使用MTT分析试验研究了这些化合物对MDA-MB-231（人类乳腺癌），A549（肺癌），Ovcar3（人类卵巢癌）和Panc1（人类胰腺癌）细胞系的影响。化合物4 - 8表现出对所有细胞系的细胞毒性的关键作用。