The bioactive glass (BG) system of SiO₂-P₂O₅CaO-SrO-Ag₂O-ZnO was synthesized by the sol-gel route. Transmission electron microscopy (TEM) analysis showed that the mean particle size of as-synthesized nanoglass was ~50 nm. The effect of zinc and silver content on cell viability, antibacterial properties, and the formation of hydroxyapatite (HA) on the BGs were investigated. The synthesized compounds were soaked in simulated body fluid (SBF) for 21 days to study the bioactivity of the new glass composition. Results demonstrated that samples BG and BG-A2Z3 showed higher bioactivities in comparison with other specimens. The formation of HA was observed on the first day of soaking. In order to investigate the biocompatibility and antibacterial properties of the samples, MTT assay and antibacterial tests against E. coli were performed. The BG-A2Z3 sample showed the optimal properties of antibacterial, biocompatibility, and bioactivity that is the best candidate for orthopedic applications.

SiO ₂ -P ₂ O ₅ CaO-SrO-Ag ₂的生物活性玻璃（BG）系统O-ZnO是通过溶胶-凝胶法合成的。透射电子显微镜（TEM）分析表明，合成后的纳米玻璃的平均粒径约为50 nm。研究了锌和银含量对细胞活力，抗菌性能以及BGs上羟基磷灰石（HA）形成的影响。将合成的化合物浸泡在模拟体液（SBF）中21天，以研究新玻璃组合物的生物活性。结果表明，样品BG和BG-A2Z3与其他样品相比具有更高的生物活性。在浸泡的第一天观察到HA的形成。为了研究样品的生物相容性和抗菌性能，进行了MTT分析和针对大肠杆菌的抗菌测试。BG-A2Z3样品显示出最佳的抗菌性能，