BACKGROUND Marked decreases in serum creatine kinase levels have been noted in Duchenne and Becker muscular dystrophies as rare complications of autoimmune or autoinflammatory diseases. SUBJECTS AND METHODS The influence of systemic inflammation on serum creatine kinase levels was reviewed from the charts of three subjects with Fukuyama congenital muscular dystrophy. RESULTS A total of 30 infectious events were identified. Elevated serum C-reactive protein levels coincided with decreased creatine kinase levels on 19 occasions. In one subject, administration of 2 mg/kg/d prednisolone for bronchial asthma resulted in a decrease in creatine kinase level on six other occasions. CONCLUSION Apart from an increase in endogenous cortisol secretion, certain inflammation-related molecules could play a role in mitigating muscle cell damage in Fukuyama congenital muscular dystrophy during febrile infectious episodes. Corticosteroids may be a promising agent for the treatment of muscular symptoms in this disorder.

中文翻译：

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福山先天性肌营养不良症患者血清肌酸激酶水平与感染相关的降低

背景 在 Duchenne 和 Becker 肌营养不良症中已经注意到血清肌酸激酶水平的显着降低，这是自身免疫或自身炎症性疾病的罕见并发症。受试者和方法 从三名福山先天性肌营养不良受试者的图表中回顾全身性炎症对血清肌酸激酶水平的影响。结果 共确定了 30 次感染事件。19 次血清 C 反应蛋白水平升高与肌酸激酶水平降低一致。在一名受试者中，给予 2 mg/kg/d 泼尼松龙治疗支气管哮喘导致其他六次肌酸激酶水平降低。结论除了内源性皮质醇分泌增加外，某些炎症相关分子可以在发热感染发作期间减轻福山先天性肌营养不良症的肌细胞损伤。皮质类固醇可能是治疗这种疾病肌肉症状的有希望的药物。