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Bioinspired membrane provides periosteum-mimetic microenvironment for accelerating vascularized bone regeneration
Biomaterials ( IF 14.0 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.biomaterials.2020.120561
Gaojie Yang , Haoming Liu , Yi Cui , Jiaqi Li , Xuan Zhou , Nuoxin Wang , Feige Wu , Yan Li , Yu Liu , Xingyu Jiang , Shengmin Zhang

Periosteum plays a pivotal role in vascularization, ossification and remodeling during the healing process of bone injury. However, there are few studies focused on the construction of artificial implants with periosteum-mimetic effect. To emulate the primary role of natural periosteum or endosteal tissues in bone regeneration, here we provide a functional biomimetic membrane with micropatterns of site-specific biomineralization. The micropattern is generated by using printed hydroxyapatite nanoparticles (HANPs), combined with selective growth of biomineralized apatite and in situ coprecipitation with growth factors. The biomimetic membrane can sustainably provide a periosteum-mimetic microenvironment, such as long-term topographical guidance for cell recruitment and induced cell differentiation, by releasing calcium phosphate and growth factors. We demonstrated that rat mesenchymal stem cells (rMSCs) on such biomimetic membrane exhibited highly aligned organization, leading to enhanced angiogenesis and osteogenesis. In the rat calvarial defect model, our biomimetic membranes with biomineralized micropatterns could significantly enhance vascularized ossification and accelerate new bone formation. The current work suggests that the functionally biomimetic membranes with specific biomineralized micropatterns can be a promising alternative to periosteal autografts, with great potential for bench-to-bedside translation in orthopedics.



中文翻译:

受生物启发的膜提供了类似骨膜的微环境,可加速血管化的骨再生

骨膜在骨损伤愈合过程中的血管化,骨化和重塑中起着关键作用。然而,很少有研究关注具有骨膜模拟效果的人造植入物的构造。为了模拟天然骨膜或骨膜内组织在骨再生中的主要作用,这里我们提供了一种具有仿生功能的仿生膜,具有特定部位的矿化微模式。通过使用印刷的羟基磷灰石纳米颗粒(HANP)结合生物矿化磷灰石的选择性生长和原位生成微图案与生长因子共沉淀。仿生膜可以通过释放磷酸钙和生长因子来持续地提供类似骨膜的微环境,例如用于细胞募集和诱导细胞分化的长期地形学指导。我们证明了在这种仿生膜上的大鼠间充质干细胞(rMSCs)表现出高度对齐的组织,导致增强的血管生成和成骨作用。在大鼠颅骨缺损模型中,具有生物矿化微模式的仿生膜可以显着增强血管化骨化并加速新骨的形成。目前的研究表明,具有特定生物矿化微模式的功能仿生膜可以替代骨膜自体移植,

更新日期:2020-12-11
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