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Analysis of steroid profiles by mass spectrometry: A new tool for exploring adrenal tumors?
Annales d'Endocrinologie ( IF 3.1 ) Pub Date : 2020-12-02 , DOI: 10.1016/j.ando.2020.12.001
Sophie Cambos 1 , Philippe Chanson 2 , Antoine Tabarin 3
Affiliation  

The assay of multiple steroids by mass spectrometry coupled with chromatography, combined with data analysis using an artificial intelligence approach, has become more widely accessible in recent years. Multiple applications for this technology exist for the study of adrenocortical tumors. Taking advantage of the capacity of malignant cortical tumor secretion of non-bioactive precursors, it provides an additional diagnostic approach that can point to the nature of a tumor. These encouraging perspectives have been based to date only on pilot retrospective studies. However, this has changed in 2020 with the publication of data from the EURINE-ACT study. This very large prospective European study provided more nuanced evidence for the benefit of combining the measurement of a panel of steroids with essential imaging tools. This study also facilitated our understanding and provided more precise characterisation of autonomous steroid secretion, particularly in the case of sublinical cortisol-secreting adrenocortical adenomas. This article will focus on our current knowledge on the potential utility of mass spectrometry for diagnosis of both the nature of an adrenal tumors and their secretion.



中文翻译:

质谱分析类固醇谱:探索肾上腺肿瘤的新工具?

近年来,通过质谱联用色谱法,结合使用人工智能方法进行数据分析,对多种类固醇的测定变得更加广泛。该技术在肾上腺皮质肿瘤的研究中有多种应用。利用恶性皮质肿瘤分泌非生物活性前体的能力,它提供了一种额外的诊断方法,可以指出肿瘤的性质。迄今为止,这些令人鼓舞的观点仅基于试点回顾性研究。但是,随着 EURINE-ACT 研究数据的发布,这种情况在 2020 年发生了变化。这项非常大型的前瞻性欧洲研究为将一组类固醇的测量与基本成像工具相结合的好处提供了更细致入微的证据。这项研究还促进了我们的理解,并提供了对自主类固醇分泌的更精确表征,特别是在亚临床皮质醇分泌肾上腺皮质腺瘤的情况下。本文将重点介绍我们目前关于质谱在诊断肾上腺肿瘤的性质及其分泌方面的潜在效用的知识。

更新日期:2021-02-07
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