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Correction of the Taxonomic Composition of Human Gut Microbiota: Serine-Threonine Protein Kinases as Biotargets
Biology Bulletin Reviews Pub Date : 2020-12-02 , DOI: 10.1134/s2079086420060080
N. V. Zakharevich , V. N. Danilenko

Abstract

The gut microbiota (GM) plays an important role in maintaining the health of the human body. Normally, the taxonomic composition of the GM is characterized by great diversity and is balanced by genus and species, but this balance is impaired by various diseases. Different approaches to the correction of the taxonomic composition of the GM are known and are currently in use. Unfortunately, most approaches simultaneously affect a wide range of microorganisms, which leads to the development of dysbiotic disorders. This study discusses the possible use of bacterial serine-threonine protein kinases (STPKs), which can be affected by selective inhibitors, as biotargets. Since most STPKs are key regulators of such important processes as cell division and growth, their inhibition will lead to slower growth and microorganism functioning. This is especially important when correction of the GM taxonomic composition requires the exposure of probiotic microorganisms. Thus, the approach proposed for discussion, the selective inhibition of bacterial STPKs, is a “softer” tool than antibiotics, and the search for suitable STPK biotargets may be the first step towards the development of effective and selective inhibitors of bacterial STPKs.



中文翻译:

人类肠道菌群的分类组成的校正:丝氨酸-苏氨酸蛋白激酶作为生物靶标。

摘要

肠道菌群(GM)在维持人体健康方面起着重要作用。通常,转基因生物的分类学特征是具有很大的多样性,并且受到属和种的平衡,但这种平衡却受到各种疾病的损害。校正GM分类学组成的不同方法是已知的,目前正在使用中。不幸的是,大多数方法同时影响广泛的微生物,从而导致营养不良性疾病的发展。这项研究讨论了可能受选择性抑制剂影响的细菌丝氨酸-苏氨酸蛋白激酶(STPKs)作为生物靶标的可能用途。由于大多数STPK是细胞分裂和生长等重要过程的关键调节剂,因此对其的抑制将导致生长和微生物功能减慢。当校正GM分类法组成需要暴露益生菌微生物时,这一点尤其重要。因此,提议用于讨论的方法,即选择性抑制细菌STPKs,是一种比抗生素更“软”的工具,寻找合适的STPK生物靶标可能是开发有效且选择性的细菌STPKs抑制剂的第一步。

更新日期:2020-12-02
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